Advances in study of PCSK9 inhibitors in treatment of non-alcoholic fatty liver disease

doi:10.16138/j.1673-6087.2024.02.09

Abstract

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is the chronic liver disease with the highest incidence rate, and its main cause is due to disorders of lipid metabolism and damage to the liver caused by ectopic fat deposition. Proprotein convertase bacillus subtilis/ kexin type 9 (PCSK9), as a lipid-regulating protease in vivo, plays a key role in abnormal lipid metabolism. Dyslipidemia levels can be significantly improved by inhibiting PCSK9 binding to receptors circulating in vivo. Therefore, PCSK9 inhibitors may improve the condition of NAFLD patients and achieve therapeutic effects.

Key words: Nonalcoholic fatty liver disease, PCSK9 inhibitor, Insulin resistance

CLC Number:

R575.5

SHEN Yun, XU Yijiao, WEI Xiao, ZHANG Ruixiang, LIU Chao. Advances in study of PCSK9 inhibitors in treatment of non-alcoholic fatty liver disease[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(02): 136-139.

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