Research progress on pathogenesis and treatment of refractory asthma in traditional Chinese medicine

doi:10.16138/j.1673-6087.2025.01.11

Abstract

Abstract:

The article focuses on research and treatment of refractory asthma as it responds poorly to conventional Chinese medicine treatments, which suggests that the disease has unique pathogenesis in traditional Chinese medicine. Exploring its specific pathogenesis will help develop more targeted treatments to improve clinical efficacy. This article systematically summarizes the views and treatments method of various scholars from three aspects: pathogenic factors, vital qi, and location of the disease. It aims to fully reveal the underlying pathogenic mechanisms of the disease and provide a basis and guidance for clinical practice and research.

Key words: Refractory asthma, Traditional Chinese medicine, Pathogenesis

CLC Number:

R562.25

DU Wei, LIU Hongwei, ZHANG Yada, CHEN Yiren, TANG Binqing. Research progress on pathogenesis and treatment of refractory asthma in traditional Chinese medicine[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(01): 54-58.

References 52

[1]	中华医学会呼吸病学分会哮喘学组. 难治性哮喘诊断与处理专家共识[J]. 中华结核和呼吸杂志, 2010, 33(8):572-577.
[2]	Chaudhuri R, McSharry C, Heaney LG, et al. Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma[J]. Respir Med, 2016,118:46-52.
[3]	Matsumura Y. Inflammatory cellular phenotypes and molecular mechanisms of glucocorticoid resistance in patients with bronchial asthma[J]. Antiinflamm Antiallergy Agents Med Chem, 2013, 12(3):189-200. doi: 10.2174/18715230113129990010 pmid: 23597084
[4]	刘红, 黄茂. 气道重塑与难治性哮喘机制的相关研究进展[J]. 医学综述, 2010, 16(6):866-868.
[5]	Mahdi B, Mahesh PA, Mysore RS, et al. Inheritance patterns, consanguinity & risk for asthma[J]. Indian J Med Res, 2010,132:48-55.
[6]	鲁艳芳. 陈陶后教授治疗难治性哮喘经验总结[J]. 中国中西医结合儿科学, 2009, 1(4):321-322.
[7]	李磊, 王蕾. “治瘀四法”论治难治性哮喘[J]. 中国药物与临床, 2016, 16(7):998-1000.
[8]	张军, 李敏, 余淑菁, 等. 崔金涛从瘀论治哮喘经验[J]. 湖南中医杂志, 2013, 29(12):22-23.
[9]	王菲, 刘鑫, 王诚喜. 白地定喘汤治疗痰热瘀阻型难治性哮喘的临床研究[J]. 世界最新医学信息文摘, 2019, 19(96):150-151.
[10]	Dürk T, Duerschmied D, Müller T, et al. Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation[J]. Am J Respir Crit Care Med, 2013, 187(5):476-485.
[11]	Yasuba H, Chihara J, Kino T, et al. Increased releasability of platelet products and reduced heparin-induced platelet factor 4 release from endothelial cells in bronchial asthma[J]. J Lipid Mediat, 1991, 4(1):5-21. pmid: 1832572
[12]	Page C, Pitchford S. Platelets and allergic inflammation[J]. Clin Exp Allergy, 2014, 44(7):901-913. doi: 10.1111/cea.12322 pmid: 24708345
[13]	Johansson MW, Han ST, Gunderson KA, et al. Platelet activation, P-selectin, and eosinophil β1-integrin activation in asthma[J]. Am J Respir Crit Care Med, 2012, 185(5):498-507.
[14]	Lefrançais E, Ortiz-Muñoz G, Caudrillier A, et al. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors[J]. Nature, 2017, 544(7648):105-109.
[15]	刘璇, 张喜莲, 宋娜. 马融治疗小儿难治性哮喘经验[J]. 中医杂志, 2020, 61(21):1871-1875.
[16]	贾琳, 魏莉瑛, 李博林, 等. 补肾祛风颗粒治疗难治性哮喘疗效观察[J]. 现代中西医结合杂志, 2019, 28(12):1260-1264.
[17]	常胜. 常青诊治难治性哮喘经验[J]. 浙江中医药大学学报, 2015(7):523-524.
[18]	杨宏志. 难治性哮喘中医辨因防治初探[J]. 中华中医药杂志, 2013, 28(3):712-714.
[19]	张岩, 宋桂华, 郭彦荣, 等. 赵坤教授“破窠囊,补肾阳”理论在儿童难治性哮喘治疗中应用[J]. 天津中医药, 2021, 38(12):1509-1512.
[20]	史锁芳. 运用大剂附子治疗难治性哮喘探讨[J]. 中华中医药学刊, 2011, 29(8):1844-1845.
[21]	朱慧志, 王胜, 杨程, 等. 胡国俊治疗难治性哮喘经验[J]. 中医药临床杂志, 2012, 24(1):20-22.
[22]	代昭欣, 程云, 于雪莲, 等. 基于“相火理论”应用潜阳封髓法治疗难治性哮喘[J]. 中医杂志, 2022, 63(9):889-893.
[23]	王和清, 李瞻. 小儿难治性哮喘的辨证与思路[J]. 中医临床研究, 2013, 5(14):62-63.
[24]	郭钊明, 黄楚栓, 刘建博, 等. 难治性哮喘的中医辨治思考[J]. 中华中医药杂志, 2019, 34(7):2928-2931.
[25]	Bray PJ, Cotton RG. Variations of the human glucocorticoid receptor gene (NR3C1): pathological and in vitro mutations and polymorphisms[J]. Hum Mutat, 2003, 21(6):557-568.
[26]	Charmandari E, Kino T, Chrousos GP. Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms[J]. Ann N Y Acad Sci, 2004,1024:168-181.
[27]	李强, 钟连英, 胡燕明, 等. 补肾止喘冲剂对难治性哮喘皮质醇和哮喘发作的作用[J]. 实用医学杂志, 2006, 22(21):2548-2550.
[28]	张文康. 中国百年百名中医临床家丛书—胡希恕[M]. 北京: 中国中医药出版社,2001:20.
[29]	王跃. 难治性哮喘证治体会[J]. 实用中医药杂志, 2002, 18(5):46.
[30]	许先科. 俞景茂从五脏相关论治小儿难治性哮喘经验[J]. 中医杂志, 2020, 61(2):110-113.
[31]	朱红, 游其君, 沈敏红. 运脾泻肺汤对难治性哮喘痰热壅肺证患儿肺功能及免疫因子的影响[J]. 浙江中医杂志, 2020, 55(9):690.
[32]	魏春华, 温明春, 于农, 等. 柴朴颗粒联合常规疗法治疗难治性哮喘临床观察[J]. 中国中西医结合杂志, 2011, 31(1):33-36.
[33]	张宏兵. 柴朴颗粒结合常规疗法治疗难治性哮喘的随机对照分析[J]. 中医临床研究, 2017, 9(10):53-54.
[34]	孙振浩. 柴朴颗粒联合常规疗法治疗难治性哮喘的效果分析[J]. 中国现代药物应用, 2015, 9(1):140-141.
[35]	王金兆. 柴朴颗粒联合常规疗法治疗难治性哮喘的临床观察[J]. 医学理论与实践, 2015, 28(1):59-60.
[36]	刘鑫, 刘姿琴, 杨苏琴, 等. 柴朴汤对肝郁型哮喘小鼠CADM1、MAL、IL-33、TSLP表达的影响[J]. 中南医学科学杂志, 2021, 49(5):502-505.
[37]	董燕萍, 张亚达, 唐斌擎. 搜剔肺络法对难治性哮喘患者诱导痰IL-1β水平的影响[J]. 中华航海医学与高气压医学杂志, 2022, 29(3):375-379.
[38]	吴以岭. 络病学[M]. 北京: 中国中医药出版社,2006:31.
[39]	唐斌擎, 石克华, 方泓, 等. 全蝎蜈蚣颗粒剂治疗难治性哮喘的临床疗效研究[J]. 天津中医药, 2019, 36(4):356-359.
[40]	张希涛, 贾新华. 基于“久病入络”探析难治性哮喘的病机演变[J]. 山东中医药大学学报, 2021, 45(5):581-584.
[41]	顾潇枫, 姜良铎, 张宇婷, 等. 难治性哮喘验案二则[J]. 环球中医药, 2018, 11(8):1297-1299.
[42]	吴洁. 润肺健脾益肾汤联合甲泼尼龙治疗小儿难治性哮喘的疗效[J]. 新疆中医药, 2023, 41(1):11-13.
[43]	孙伟伟. 润肺健脾益肾汤结合西药治疗小儿难治性哮喘41例[J]. 福建中医药, 2021, 52(4):56-57.
[44]	刘玉凤. 自拟润肺健脾益肾汤对小儿难治性哮喘肺功能、免疫因子的影响[J]. 中国医师杂志, 2018, 20(12):1803-1806.
[45]	李敏, 丁丹丹. 从肺脾肾论治儿童难治性哮喘30例临床观察[J]. 中国中医基础医学杂志, 2016, 22(3):426-427.
[46]	代媛媛. 李国勤教授治疗难治性哮喘临床验案1例[J]. 吉林中医药, 2011, 31(4):353-354.
[47]	罗世杰. 中西医结合治疗儿童慢性难治性哮喘初探[J]. 现代中医药, 2008, 28(6):24-25.
[48]	杨均立, 郭兆美. 中西医结合治疗难治性哮喘[J]. 河北医学, 1997,(3):56-57.
[49]	吴少丽. 射干麻黄汤加味辅治难治性哮喘的效果[J]. 实用临床医学, 2017, 18(2):25-26.
[50]	王晶波, 彭先祝, 隋博文. 射干麻黄汤加味治疗难治性哮喘33例临床观察[J]. 中医杂志, 2013, 54(10):846-848.
[51]	孟国奇. 射干麻黄汤加味治疗难治性哮喘的疗效观察[J]. 光明中医, 2015, 30(10):2141-2142.
[52]	曹航. 加减定喘汤治疗难治性哮喘的临床研究[J]. 中国当代医药, 2012, 19(32):126-127.