Study on correlation between nutritional risk assessment and clinical outcome in hospitalized patients with cirrhosis

doi:10.16138/j.1673-6087.2025.05.05

Abstract

Abstract:

Objective To evaluate the nutritional risk in hospitalized patients with cirrhosis and explore the relationship between nutritional risk and clinical prognosis. Methods A total of 401 patients with cirrhosis admitted to the infectious diseases department of a grade-Ⅲ hospital in Shanghai from June 2020 to June 2022 were selected as study subjects. The nutritional risk assessment was performed using the Royal Free Hospital-nutrition prioritizing tool (RFH-NPT), and the general information, disease status, laboratory indicators, and clinical prognosis of cirrhosis patients with different nutritional risks were compared. Results In 401 patients, 86 (21.45%) cases had moderate nutritional risk, and 122 (30.42%) cases had high nutritional risk. There were differences in etiological classification, model for end-stage liver disease (MELD) score, Child-Pugh grade, abdominal water volume and laboratory indexes of serum albumin, prealbumin, triglyceride and hemoglobin among patients with different nutritional risks (P < 0.05). With the increase of nutritional risk grade, the incidence of infection, upper gastrointestinal bleeding and electrolyte disturbance increased, and the score of activity of daily living decreased (P < 0.05). Conclusions Cirrhosis patients with moderate to high nutritional risk have severer liver function impairment, high complication rate and poor clinical prognosis compared to those at lower risk.

Key words: Liver cirrhosis, Nutritional risk, Clinical outcome, RFH-NPT

CLC Number:

R575.2

WANG Lin, XIANG Xiaogang, LI Li, QIAN Zhuping. Study on correlation between nutritional risk assessment and clinical outcome in hospitalized patients with cirrhosis[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(05): 376-380.

Figures/Tables 2

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Table 2

References 28

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项目	低风险（n=193）	中风险（n=86）	高风险（n=122）	x²/F	P
性别[n (%)]
男性	140（75.54）	58（67.44）	86（70.49）	0.757	0.685
女性	53（24.46）	28（32.56）	36（29.51）
年龄(岁)	56.26±12.19	54.19±13.63	55.39±11.49	0.858	0.425
病因[n (%)]
病毒性肝炎	141（73.06）	51（59.30）	74（60.66）	10.376	0.031
酒精性肝硬化	16（8.29）	7（8.14）	12（9.84）
自身免疫性肝硬化	9（4.66）	6（6.98）	12（9.84）
其他	27（13.99）	22（25.58）	24（19.66）
MELD评分	11.60±5.19	14.26±5.71	14.83±6.02	14.757	0.001
Child-Pugh分级[n (%)]
A级	99（51.30）	9（10.47）	17（13.93）	80.915	0.000
B级	76（39.38）	45（52.33）	67（54.92）
C级	18（9.32）	32（37.20）	38（31.15）
腹水量[n (%)]
无	140（72.54）	11（12.79）	40（32.79）	111.194	0.000
少量（<3 cm）	34（17.62）	30（34.88）	30（24.59）
中量（3~10 cm）	15（7.77）	30（34.88）	30（24.59）
大量（＞10 cm）	4（2.07）	15（17.45）	22（18.03）
ALB(g/L)	33.69±6.37	29.07±5.61	30.06±5.69	23.314	0.000
PAB(mg/L)	126.08±63.57	86.99±44.83	94.84±54.55	18.564	0.000
TC(mmol/L)	3.69±1.23	3.55±2.04	3.45±1.48	0.876	0.417
TG(mmol/L)	1.22±0.69	1.10±0.56	1.44±1.29	3.588	0.029
Hb(g/L)	123.60±22.17	113.23±23.90	111.30±24.09	12.520	0.000

项目	低风险（n =193）	中风险（n =86）	高风险（n =122）	x²/F	P
生存率[n (%)]	189（97.93）	86（100）	118（96.72）	2.785	0.248
住院时间(d)	20.82±23.76	22.40±16.72	25.40±18.77	1.763	0.173
并发症[n (%)]
感染	45（23.32）	24（27.91）	50（40.98）	11.344	0.003
上消化道出血	11（5.70）	7（8.14）	17（13.93）	6.411	0.041
肾功能不全	50（25.91）	20（23.26）	30（24.59）	0.235	0.889
电解质紊乱	51（26.42）	34（39.53）	56（45.90）	13.356	0.001
轻微型肝性脑病	86（44.56）	38（44.19）	64（52.46）	2.193	0.334
并发症总体发生率	132（68.39）	68（79.07）	106（86.89）	14.600	0.001
BI	98.11±7.51	96.86±9.11	94.96±13.57	3.675	0.026