外科理论与实践 ›› 2020, Vol. 25 ›› Issue (03): 263-268.doi: 10.16139/j.1007-9610.2020.03.018
陈国骥 综述, 杨华, 王存川 审校(
)
收稿日期:2020-01-10
出版日期:2020-05-25
发布日期:2020-05-25
通讯作者:
王存川
E-mail:twcc@jnu.edu.cn
CHEN Guoji, YANG Hua, WANG Cunchuan()
Received:2020-01-10
Online:2020-05-25
Published:2020-05-25
中图分类号:
陈国骥, 杨华, 王存川. 减重手术在肥胖合并Prader-Willi综合征病人的应用效果[J]. 外科理论与实践, 2020, 25(03): 263-268.
CHEN Guoji, YANG Hua, WANG Cunchuan. Outcomes of bariatric surgery in obese patients with Prader-Willi syndrome[J]. Journal of Surgery Concepts & Practice, 2020, 25(03): 263-268.
表1
PWS病人减重手术前、后情况（n=11）
| 文献 | 发表 年份 | 例数 | 术前基本情况 | 术前体重(kg)/BMI | 术式 | 随访 时间 | EWL | 术后疗效 |
|---|---|---|---|---|---|---|---|---|
| 吴佳君等[ | 2011 | 1 | 男,18岁,2 型糖尿病、高血压病、高脂血症和OSAS | 109/45.4 | SG | 4个月 | 26.5% （减重13 kg） | 无并发症发生,血糖、肝功能等指标改善,胰岛素用量减少 |
| 高蔚等[ | 2012 | 1 | 男,13岁,重度OSAS | 160 | LSG | NA | NA | NA |
| Fong等[ | 2012 | 3 | 女2例,男1例,（18.7±4.0） （15~23）岁,轻度至中度 OSAS,女1例合并食管炎和食管裂孔疝,空腹血浆 Ghrelin：1134.2±1 704.7 （294.9~2 247.5）ng/L | 96.4~120.7/44~50 | LMGB（1例） LSG（2例） | 24个月 | 平均63.2%± 20.0%（50.5%~ 86.2%） | 空腹血浆Ghrelin： 519.8±593.1(119.7~ 1201.2）ng/L,LMGB术 后1年出现缺铁性贫 血,摄食行为改善 |
| Yu等[ | 2013 | 1 | 女,17岁,2型糖尿病,呼吸困难,重度OSAS | 94.2/46.7 | LSG | 15个月 | 61.2%（减重 26.8 kg） | 无术后并发症发生,2型糖尿病完全缓解,余并发症改善明显 |
| Liu等[ | 2020 | 5 | 男2例,女3例,19.2±3.0（15~23）岁,2型糖尿病（2例）、OSAS（5例） | 96.6±18.8（68.4~ 120.7）/47.3±6.9 （38.4~57.4） | LSG(2例) OAGB(2例) LRYGB(1例) | 3例10年,2例6年 | 术后6年19.7%± 20.8%（1.4%~ 42.7%）,术后 10年-1.2%±3.9% （-1.3%~5.7%） | 术后10年并发症无明 显改善,2例新发高血 压病。1例OAGB术后 78个月（27岁）疑因睡 眠中呼吸暂停死亡 |
| [1] | Cassidy SB, Schwartz S, Miller JL, et al. Prader-Willi syndrome[J]. Genet Med, 2012, 14(1):10-26. |
| [2] |
Lionti T, Reid SM, White SM, et al. A population-based profile of 160 Australians with Prader-Willi syndrome: trends in diagnosis, birth prevalence and birth characte-ristics[J]. Am J Med Genet A, 2015, 167A(2):371-378.
doi: 10.1002/ajmg.a.36845 pmid: 25424396 |
| [3] | 中华医学会儿科学分会内分泌遗传代谢学组, 《中华儿科杂志》编辑委员会. 中国Prader-Willi综合征诊治专家共识(2015)[J]. 中华儿科杂志, 2015, 53(6):419-424. |
| [4] |
Crino A, Fintini D, Bocchini S, et al. Obesity management in Prader-Willi syndrome: current perspectives[J]. Diabetes Metab Syndr Obes, 2018, 11:579-593.
doi: 10.2147/DMSO.S141352 URL |
| [5] |
Kim Y, Wang SE, Jiang YH. Epigenetic therapy of Prader-Willi syndrome[J]. Transl Res, 2019, 208:105-118.
doi: 10.1016/j.trsl.2019.02.012 URL |
| [6] |
Butler MG, Kimonis V, Dykens E, et al. Prader-Willi syndrome and early-onset morbid obesity NIH rare di-sease consortium: A review of natural history study[J]. Am J Med Genet A, 2018, 176(2):368-375.
doi: 10.1002/ajmg.a.38582 URL |
| [7] |
Polex-Wolf J, Lam BY, Larder R, et al. Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome[J]. J Clin Invest, 2018, 128(3):960-969.
doi: 10.1172/JCI97007 pmid: 29376887 |
| [8] |
Bohonowych J, Miller J, McCandless SE, et al. The glo-bal Prader-Willi syndrome registry: development, launch, and early demographics[J]. Genes (Basel), 2019, 10(9):713.
doi: 10.3390/genes10090713 URL |
| [9] |
Muscogiuri G, Formoso G, Pugliese G, et al. Prader-Willi syndrome: An uptodate on endocrine and metabolic complications[J]. Rev Endocr Metab Disord, 2019, 20(2):239-250.
doi: 10.1007/s11154-019-09502-2 URL |
| [10] |
McCandless SE, Committee on Genetics. Clinical report-health supervision for children with Prader-Willi syndrome[J]. Pediatrics, 2011, 127(1):195-204.
doi: 10.1542/peds.2010-2820 pmid: 21187304 |
| [11] |
Kimonis VE, Tamura R, Gold JA, et al. Early diagnosis in Prader-Willi syndrome reduces obesity and associated co-morbidities[J]. Genes (Basel), 2019, 10(11):898
doi: 10.3390/genes10110898 URL |
| [12] |
Khan MJ, Gerasimidis K, Edwards CA, et al. Mechanisms of obesity in Prader-Willi syndrome[J]. Pediatr Obes, 2018, 13(1):3-13.
doi: 10.1111/ijpo.12177 pmid: 27863129 |
| [13] | Tauber M, Coupaye M, Diene G, et al. Prader-Willi syndrome: A model for understanding the ghrelin system[J]. J Neuroendocrinol, 2019, 31(7):e12728. |
| [14] |
Feigerlova E, Diene G, Conte-Auriol F, et al. Hyperghrelinemia precedes obesity in Prader-Willi syndrome[J]. J Clin Endocrinol Metab, 2008, 93(7):2800-2805.
doi: 10.1210/jc.2007-2138 URL |
| [15] |
Dykens EM, Roof E, Hunt-Hawkins H. Cognitive and adaptive advantages of growth hormone treatment in children with Prader-Willi syndrome[J]. J Child Psychol Psychiatry, 2017, 58(1):64-74.
doi: 10.1111/jcpp.12601 URL |
| [16] | Stipancic G, Pozgaj Sepec M, La Grasta Sabolic L. Effect of growth hormone therapy in children with Prader-Willi syndrome-our first experiences[J]. Acta Clin Croat, 2018, 57(4):744-755. |
| [17] | Butler MG, Matthews NA, Patel N, et al. Impact of gene-tic subtypes of Prader-Willi syndrome with growth hormone therapy on intelligence and body mass index[J]. Am J Med Genet A, 2019, 179(9):1826-1835. |
| [18] |
Alsaif M, Elliot SA, MacKenzie ML, et al. Energy metabolism profile in individuals with Prader-Willi syndrome and implications for clinical management: a systematic review[J]. Adv Nutr, 2017, 8(6):905-915.
doi: 10.3945/an.117.016253 pmid: 29141973 |
| [19] | Colquitt JL, Pickett K, Loveman E, et al. Surgery for weight loss in adults[J]. Cochrane Database Syst Rev, 2014,(8): CD003641. |
| [20] | 王存川, 张鹏, 杨景哥, 等. 中国儿童和青少年肥胖症外科治疗指南(2019版)[J]. 中华肥胖与代谢病电子杂志, 2019, 5(1): 3-9. |
| [21] |
Bussler S, Penke M, Flemming G, et al. Novel insights in the metabolic syndrome in childhood and adolescence[J]. Horm Res Paediatr, 2017, 88(3-4):181-193.
doi: 10.1159/000479510 URL |
| [22] |
Shoar S, Mahmoudzadeh H, Naderan M, et al. Long-term outcome of bariatric surgery in morbidly obese adolescents: a systematic review and meta-analysis of 950 patients with a minimum of 3 years follow-up[J]. Obes Surg, 2017, 27(12):3110-3117.
doi: 10.1007/s11695-017-2738-y URL |
| [23] |
Inge TH, Courcoulas AP, Jenkins TM, et al. Five-year outcomes of gastric bypass in adolescents as compared with adults[J]. N Engl J Med, 2019, 380(22):2136-2145.
doi: 10.1056/NEJMoa1813909 URL |
| [24] |
Adams TD. In teens with severe obesity, can bariatric surgery wait until adulthood?[J]. N Engl J Med, 2019, 380(22):2175-2177.
doi: 10.1056/NEJMe1905778 URL |
| [25] |
Schrander-Stumpel CT, Curfs LM, Sastrowijoto P, et al. Prader-Willi syndrome: causes of death in an internatio-nal series of 27 cases[J]. Am J Med Genet A, 2004, 124A(4):333-338.
pmid: 14735579 |
| [26] |
Einfeld SL, Kavanagh SJ, Smith A, et al. Mortality in Prader-Willi syndrome[J]. Am J Ment Retard, 2006, 111(3):193-198.
doi: 10.1352/0895-8017(2006)111[193:MIPS]2.0.CO;2 URL |
| [27] |
Whittington JE, Holland AJ, Webb T, et al. Population prevalence and estimated birth incidence and mortality rate for people with Prader-Willi syndrome in one UK Health Region[J]. J Med Genet, 2001, 38(11):792-798.
pmid: 11732491 |
| [28] |
Urquhart DS, Gulliver T, Williams G, et al. Central sleep-disordered breathing and the effects of oxygen the-rapy in infants with Prader-Willi syndrome[J]. Arch Dis Child, 2013, 98(8):592-595.
doi: 10.1136/archdischild-2012-303441 pmid: 23761691 |
| [29] |
Zanella S, Tauber M, Muscatelli F. Breathing deficits of the Prader-Willi syndrome[J]. Respir Physiol Neurobiol, 2009, 168(1-2):119-124.
doi: 10.1016/j.resp.2009.03.010 URL |
| [30] |
Manzardo AM, Loker J, Heinemann J, et al. Survival trends from the Prader-Willi Syndrome Association (USA) 40-year mortality survey[J]. Genet Med, 2018, 20(1):24-30.
doi: 10.1038/gim.2017.92 pmid: 28682308 |
| [31] | 吴佳君, 乔洁, 韩兵, 等. 一例Prader-Willi综合征的基因诊断和减重手术治疗[J]. 中华内分泌代谢杂志, 2011, 27(6):498-501. |
| [32] | 高蔚, 顾莺, 罗飞宏, 等. 1例Prader-Willi综合征行腹腔镜袖状胃减容术患儿的护理[J]. 护理学杂志, 2012, 27(24):27-28. |
| [33] |
Fong AK, Wong SK, Lam CC, et al. Ghrelin level and weight loss after laparoscopic sleeve gastrectomy and gastric mini-bypass for Prader-Willi syndrome in Chinese[J]. Obes Surg, 2012, 22(11):1742-1745.
doi: 10.1007/s11695-012-0725-x URL |
| [34] |
Yu H, Di J, Jia W. Laparoscopic sleeve gastrectomy in Chinese female patient with Prader-Willi syndrome and diabetes[J]. Surg Obes Relat Dis, 2013, 9(2):e25-e27.
doi: 10.1016/j.soard.2012.07.009 URL |
| [35] | Liu SY, Wong SK, Lam CC, et al. Bariatric surgery for Prader-Willi syndrome was ineffective in producing sustainable weight loss: Long term results for up to 10 years[J]. Pediatr Obes, 2020, 15(1):e12575. |
| [36] |
Brethauer SA, Kim J, El Chaar M, et al. Standardized outcomes reporting in metabolic and bariatric surgery[J]. Obes Surg, 2015, 25(4):587-606.
doi: 10.1007/s11695-015-1645-3 pmid: 25802064 |
| [37] |
Oria HE, Moorehead MK. Updated bariatric analysis and reporting outcome system (BAROS)[J]. Surg Obes Relat Dis, 2009, 5(1):60-66.
doi: 10.1016/j.soard.2008.10.004 URL |
| [38] |
Alqahtani AR, Elahmedi MO, Al Qahtani AR, et al. Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: a matched-control study[J]. Surg Obes Relat Dis, 2016, 12(1):100-110.
doi: 10.1016/j.soard.2015.07.014 pmid: 26431633 |
| [39] |
Marceau P, Marceau S, Biron S, et al. Long-term expe-rience with duodenal switch in adolescents[J]. Obes Surg, 2010, 20(12):1609-1616.
doi: 10.1007/s11695-010-0262-4 pmid: 20835899 |
| [40] |
Musella M, Milone M, Leongito M, et al. The mini-gastric bypass in the management of morbid obesity in Prader-Willi syndrome: a viable option?[J]. J Invest Surg, 2014, 27(2):102-105.
doi: 10.3109/08941939.2013.832824 pmid: 24063639 |
| [41] |
Cazzo E, Gestic MA, Utrini MP, et al. Bariatric surgery in individuals with severe cognitive impairment: report of two cases[J]. Sao Paulo Med J, 2018, 136(1):84-88.
doi: 10.1590/1516-3180.2016.0299071216 URL |
| [42] |
Martinelli V, Chiappedi M, Pellegrino E, et al. Laparoscopic sleeve gastrectomy in an adolescent with Prader-Willi syndrome: psychosocial implications[J]. Nutrition, 2019, 61:67-69.
doi: S0899-9007(18)30249-1 pmid: 30703571 |
| [43] |
Pratt JSA, Browne A, Browne NT, et al. ASMBS pediatric metabolic and bariatric surgery guidelines, 2018[J]. Surg Obes Relat Dis, 2018, 14(7):882-901.
doi: 10.1016/j.soard.2018.03.019 URL |
| [44] |
Gibbons E, Casey AF, Brewster KZ. Bariatric surgery and intellectual disability: Furthering evidence-based practice[J]. Disabil Health J, 2017, 10(1):3-10.
doi: S1936-6574(16)30133-9 pmid: 27720223 |
| [45] |
Randolph JG, Weintraub WH, Rigg A. Jejunoileal bypass for morbid obesity in adolescents[J]. J Pediatr Surg, 1974, 9(3):341-345.
pmid: 4843988 |
| [46] |
Laurent-Jaccard A, Hofstetter JR, Saegesser F, et al. Long-term result of treatment of Prader-Willi syndrome by scopinaro's bilio-pancreatic diversion. study of three cases and the effect of dextrofenfluramine on the posto-perative evolution[J]. Obes Surg, 1991, 1(1):83-87.
pmid: 10715667 |
| [47] |
Marinari GM, Camerini G, Novelli GB, et al. Outcome of biliopancreatic diversion in subjects with Prader-Willi syndrome[J]. Obes Surg, 2001, 11(4):491-495.
pmid: 11501362 |
| [48] |
Vilallonga R, Moreno Villares JM, Yeste Fernandez D, et al. Initial approach to childhood obesity in spain. a multisociety expert panel assessment[J]. Obes Surg, 2017, 27(4):997-1006.
doi: 10.1007/s11695-016-2413-8 pmid: 27752806 |
| [49] | 王勇, 王存川, 朱晒红, 等. 中国肥胖及2型糖尿病外科治疗指南(2019版)[J]. 中国实用外科杂志, 2019, 39(4):301-306. |
| [50] |
Papavramidis ST, Kotidis EV, Gamvros O. Prader-Willi syndrome-associated obesity treated by biliopancreatic diversion with duodenal switch. Case report and literature review[J]. J Pediatr Surg, 2006, 41(6):1153-1158.
pmid: 16769352 |
| [51] |
de Almeida MQ, Cercato C, Rascovski A, et al. Results of biliopancreatic diversion in two patients with Prader-Willi syndrome[J]. Obes Surg, 2005, 15(6):901-904.
doi: 10.1381/0960892054222885 URL |
| [52] |
Grugni G, Guzzaloni G, Morabito F. Failure of biliopancreatic diversion in Prader-Willi syndrome[J]. Obes Surg, 2000, 10(2):179-182.
pmid: 10782182 |
| [53] |
Antal S, Levin H. Biliopancreatic diversion in Prader-Willi syndrome associated with obesity[J]. Obes Surg, 1996, 6(1):58-62.
pmid: 10731252 |
| [54] |
Brossy JJ. Biliopancreatic bypass in the Prader-Willi syndrome[J]. Br J Surg, 1989, 76(3):313.
doi: 10.1002/bjs.1800760331 URL |
| [55] |
Robert M, Espalieu P, Pelascini E, et al. Efficacy and safety of one anastomosis gastric bypass versus Roux-en-Y gastric bypass for obesity (YOMEGA): a multicentre, randomised, open-label, non-inferiority trial[J]. Lancet, 2019, 393(10178):1299-1309.
doi: S0140-6736(19)30475-1 pmid: 30851879 |
| [56] |
Kobayashi J, Kodama M, Yamazaki K, et al. Gastric bypass in a Japanese man with Prader-Willi syndrome and morbid obesity[J]. Obes Surg, 2003, 13(5):803-805.
pmid: 14627483 |
| [57] |
Thuilleaux D, Laurier V, Copet P, et al. A model to characterize psychopathological features in adults with Prader-Willi syndrome[J]. Am J Med Genet A, 2018, 176(1):41-47.
doi: 10.1002/ajmg.a.38525 pmid: 29150898 |
| [58] |
Galioto R, Gunstad J, Heinberg LJ, et al. Adherence and weight loss outcomes in bariatric surgery: does cognitive function play a role?[J]. Obes Surg, 2013, 23(10):1703-1710.
doi: 10.1007/s11695-013-1060-6 pmid: 23934274 |
| [59] | Mason EE, Maher JW, Scott DH. Ten years of vertical banded gastroplasty for severe obesity[J]. Probl Gen Surg, 1992, 9:280-289. |
| [1] | 叶雅芬, 杨颖, 韩峻峰. 脂肪组织衰老的细胞学改变及其分子机制研究进展[J]. 诊断学理论与实践, 2022, 21(05): 650-654. |
| [2] | 宣呈杰, 卞冬生, 蒋咏梅, 陈宇菲, 金佳斌, 施咏梅. 营养治疗对减重术后身体成分及静息能量消耗的影响[J]. 外科理论与实践, 2022, 27(03): 244-248. |
| [3] | 陈孚, 李震, 周勇, 王勇. 肥胖合并呼吸衰竭病人的减重代谢手术（附1例报告）[J]. 外科理论与实践, 2020, 25(05): 440-441. |
| [4] | 王存川, 赵鑫, 杨华. 减重代谢手术的术式和选择[J]. 外科理论与实践, 2020, 25(03): 195-197. |
| [5] | 袁理蕙, 洪洁,. 减重手术治疗肥胖相关男性性腺功能减退症研究进展及机制探讨[J]. 内科理论与实践, 2019, 14(02): 135-140. |
| [6] | 马驰野, 朱江帆, 马颖璋, 满琳, 陆伟, 张启颖, 张亚丽. 腹腔镜胃袖状切除术对肥胖型多囊卵巢综合征代谢的影响（附33例报告）[J]. 外科理论与实践, 2018, 23(06): 506-510. |
| [7] | 朱江帆. 减重与代谢手术方式演变及启示[J]. 外科理论与实践, 2018, 23(06): 477-480. |
| [8] | 花荣, 姚琪远. 病态肥胖伴胃食管反流病的减重术式选择[J]. 外科理论与实践, 2018, 23(06): 499-501. |
| [9] | 范志宁, 王建坤. 内镜减重手术的现状和未来[J]. 外科理论与实践, 2018, 23(06): 502-505. |
| [10] | 汪运节, 郭海军, 曹东亮, 马颖璋, 朱江帆. 术前饮食行为对减重手术效果的影响[J]. 外科理论与实践, 2018, 23(06): 511-514. |
| [11] | 沈佳慧, 杨珵璨, 王文越, 张雨翔, 徐华, 李昆, 戴谦诚, 王兵. 三孔法在腹腔镜胃袖状切除术中的应用[J]. 外科理论与实践, 2018, 23(06): 515-518. |
| [12] | 丁锐, 姚琪远,. 减重术后的管理策略[J]. 外科理论与实践, 2017, 22(06): 479-482. |
| [13] | 朱翠玲, 钱春花, 张怡, 高晶扬, 尤慧, 卢列盛, 董恒生, 周东雷, 曲伸,. 代谢性手术治疗重度肥胖伴非酒精性脂肪性肝病患者的疗效观察[J]. 内科理论与实践, 2017, 12(04): 256-261. |
| [14] | 邓莉, 宋丹, 张燕, 刘勋,. 肥胖症相关基因rs9939609单核苷酸多态性和肥胖在多囊卵巢综合征中交互作用的研究[J]. 诊断学理论与实践, 2016, 15(03): 308-311. |
| [15] | 邓侠兴, 应夏洋,. 极重度肥胖病人行减重及代谢手术的围手术期处理[J]. 外科理论与实践, 2015, 20(05): 375-378. |
| 阅读次数 | ||||||
|
全文 |
|
|||||
|
摘要 |
|
|||||
