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    25 August 2026, Volume 31 Issue 04 Previous Issue   
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    Editorial
    From case volume to learning systems: pathways and prospects for thyroid oncology discipline development
    WANG Yu
    2026, 31 (04):  279-286.  DOI: 10.16139/j.1007-9610.2026.04.01
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    In recent years, the incidence of thyroid cancer in China has risen steadily, rendering it one of the most rapidly increasing solid malignancies nationwide. Relative to Western populations, China confronts a “dual disease burden”: a substantial cohort of patients with low-risk papillary thyroid carcinoma coexists alongside pressing clinical needs for effective management of advanced and high-risk disease. Consequently, implementing risk-stratified management for low-risk patients—while delivering intensified, multimodal therapeutic strategies for high-risk cases—has emerged as a pivotal challenge in advancing thyroid oncology in China. This article presented a systematic review of the evolution of thyroid tumor disciplines in China, synthesizing cutting-edge domestic and international research evidence alongside recent institutional innovations at Fudan University Shanghai Cancer Center. It underscored four critical enablers of discipline advancement: (1) high-quality, standardized clinical databases and biobanks as foundational infrastructure; (2) artificial intelligence (AI)-driven enhancements in data curation, dynamic risk stratification, and longitudinal care coordination; (3) neoadjuvant therapy as an integral pillar of precision medicine for locally advanced or high-risk thyroid cancer; and (4) robust multidisciplinary collaboration and scalable national research networks as essential organizational frameworks for investigating rare and aggressive subtypes. Looking ahead, China is well positioned to adapt proven translational research paradigms from lung and breast cancer—particularly those grounded in learning health systems—to establish a data-informed, multidisciplinary collaboration, and iteratively refined learning health system of precision medicine, thereby contributing a distinctive, evidence-based Chinese model for optimized diagnosis and treatment for thyroid cancer.

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    Application and innovation of nerve monitoring technology in robotic thyroid surgery
    WANG Ning, BAI Kecheng, ZHANG Daqi
    2026, 31 (04):  287-292.  DOI: 10.16139/j.1007-9610.2026.04.02
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    The clinical application of robotic thyroid surgery has become increasingly widespread; however, factors, including the constrained operative space and the lack of tactile feedback in robotic systems, present multiple challenges to the effective use of intraoperative nerve monitoring (IONM). In recent years, investigators have continuously advanced the application and development of IONM in robotic thyroid surgery through diverse strategies, including optimization of probe approaches, modification of dedicated instruments, refinement of monitoring modalities, and targeted nerve preservation. This article systematically examined the current research landscape and recent progress, analyzed the efficacy and limitations of existing strategies, and explored innovative approaches to safer and more efficient IONM in robotic thyroid surgery, with the aim of informing further optimization and broader clinical adoption.

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    Experts forum
    Diagnosis and treatment of chylous leakage following cervical lymph node dissection for thyroid cancer
    LI He, AI Zhilong
    2026, 31 (04):  293-299.  DOI: 10.16139/j.1007-9610.2026.04.03
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    Chylous leakage is an uncommon but potentially severe complication following cervical lymph node dissection for thyroid cancer. Persistent or high-output leakage may result in hypoproteinemia, malnutrition, fluid and electrolyte disturbances, immunosuppression, wound infection, skin-flap necrosis, and chylothorax, and in severe cases, it may cause respiratory or circulatory compromise. Based on the Chinese expert consensus, recent case series, retrospective studies, and personal experiences, this paper summarized the epidemiology, risk factors, clinical classification, diagnostic pathways, stepwise treatment strategies, and prognosis of chylous leakage, providing a reference for standardized and individualized clinical management.

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    Application and prospects of AI-assisted multi-omics for diagnosis and treatment of thyroid cancer
    CAI Xue, WANG Yingrui, GUO Tiannan
    2026, 31 (04):  300-305.  DOI: 10.16139/j.1007-9610.2026.04.04
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    Thyroid cancer, the most common malignancy of the endocrine system, is undergoing a profound transformation in precision diagnosis and treatment driven jointly by artificial intelligence (AI) and multi-omics technologies. Confronted with longstanding challenges, including the strong subjectivity of ultrasound interpretation, diagnostic uncertainty in cytology, difficulty in preoperative differentiation of follicular neoplasms, and the lack of precise indicators for recurrence risk assessment, this field is gradually shifting from a traditional paradigm reliant on a single information dimension and empirical judgment toward a data-driven, multidimensional integrative approach to precision diagnosis and treatment. First, leveraging the advantages of deep learning and computer vision, AI technologies have significantly improved the accuracy and efficiency of intelligent ultrasound image interpretation, shifting nodule malignancy differentiation from experience-dominated practice toward AI-assisted decision-making. Second, multi-omics technologies such as genomics and proteomics have systematically revealed key driver genes and molecular biomarkers associated with thyroid nodules, providing important supplementary information for the precise classification of indeterminate nodules. Meanwhile, AI models integrating multilevel information from genomics, proteomics, and other omics layers have demonstrated distinct advantages in diagnostic performance and recurrence risk prediction, offering new insights for individualized treatment decision-making and continuous patient monitoring. Overall, research on AI-driven multi-omics approaches in thyroid nodules has progressed from isolated technical exploration toward multidimensional integration aimed at clinical translation.

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    Original article
    Tumor size as a predictor for preoperative assessment of cervical lymph node metastasis in medullary thyroid carcinoma: a retrospective study based on the SEER database
    TIAN Yuan, LIU Xun
    2026, 31 (04):  306-318.  DOI: 10.16139/j.1007-9610.2026.04.05
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    Objective To systematically evaluate influencing factors of cervical lymph node metastasis in medullary thyroid carcinoma (MTC) patients using the SEER database, with a focus on the dose-response relationship between tumor size and lymph node metastasis, and to determine the optimal clinical cut-off value. Methods A total of 2,875 MTC patients diagnosed between 2000 and 2023 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate logistic regression were used to identify independent predictors, with Poisson regression estimating risk ratios (RR). Restricted cubic spline (RCS) assessed the dose-response relationship, and maximally selected rank statistics (MAXSTAT) determined the optimal cut-off value. Model performance was assessed through internal validation, calibration curves, and decision curve analysis (DCA), and sensitivity analyses were conducted stratified by the extent of lymph node dissection. Results Multivariate logistic regression and sensitivity analyses showed that female sex (OR=0.40, P<0.001) and age ≥75 years (OR=0.40, P<0.001) were protective factors, while tumor size was a significant independent risk factor (P<0.001). RCS revealed an approximate log-linear relationship between tumor size and lymph node metastasis risk (overall P<0.001). The optimal cut-off was diameter 12 mm; using this threshold, >12 mm group had a significantly higher metastasis rate than the ≤12 mm group (52.6% vs. 20.2%, OR=4.38, P<0.001). Internal validation yielded an area under the receiver operating characteristic curve (AUC) of 0.657 (95% CI: 0.629-0.686), with calibration curves and DCA indicating clinical net benefit. Sensitivity analyses confirmed the robustness of the tumor size effect across different dissection extent subgroups. Conclusions Tumor size is an important independent predictor of lymph node metastasis in MTC. The 12 mm threshold may serve as a candidate ancillary tool for preoperative risk stratification, prompting enhanced imaging evaluation. This threshold should be interpreted in conjunction with calcitonin levels, RET mutation status, and clinical N stage to inform treatment planning. Given the absence of these molecular and biochemical data in the SEER database, this threshold alone cannot be used as an independent criterion for determining the extent of lymph node dissection.

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    Significance of peritoneal lavage cytology at different sampling time points of radical gastrectomy
    LI Hualin, XIANG Rongchao, ZOU Hongbo, CHEN Guofeng
    2026, 31 (04):  319-325.  DOI: 10.16139/j.1007-9610.2026.04.06
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    Objective To explore the influence of peritoneal lavage cytology at different sampling time points on the detection rate of intraperitoneal free cancer cells (IFCCs) in the abdominal cavity during radical gastrectomy. Methods Retrospective analysis of clinicopathological data of peritoneal lavage cytology in 125 patients with advanced gastric cancer undergoing radical gastrectomy. Peritoneal lavage fluid samples was collected before and after operation, and cytopathology examination was conducted respectively. The relationship between positive cytology (CY1) detection rate of peritoneal lavage and sampling time points of peritoneal lavage cytology, and the related clinicopathological characteristics affecting the detection rate was analyzed. Results There were 27 cases (21.6%) of CY1 patients before operation and 43 cases (34.4%) after operation. Univariate analysis revealed statistically significant differences in tumor differentiation, T stage, N stage between the preoperative CY1 and CY0 groups (P<0.05), as well as in tumor differentiation, T stage, N stage, and operation time between the postoperative CY1 and CY0 groups (P<0.05). Multivariate mixed-effects logistic regression analysis showed that the postoperative CY1 detection status (positive/negative) was only associated with tumor T stage, N stage and lavage cytology examination time points. Conclusions Peritoneal lavage cytology examination time points is a factor affecting the detection rate of CY1 in advanced gastric cancer. Postoperative sampling yielded a higher detection rate, suggesting that sampling time point impacts detection. The elevated positivity associated with intraoperative procedures awaits validation by prospective studies. It is suggested that peritoneal lavage cytology should be performed after operation and before closing abdomen to improve the detection rate of CY1.

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    Analysis of influencing factors of placement of pancreatic duct stent on recurrence of extrahepatic bile duct stones after ERCP lithotomy combined with ERBD
    WANG Yubin, ZHANG Honglei, ZHANG Cheng, KONG Xiangyu, XIANG Yukai, YANG Yulong
    2026, 31 (04):  326-334.  DOI: 10.16139/j.1007-9610.2026.04.07
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    Objective To investigate the impact of pancreatic duct stent on long-term recurrence of extrahepatic bile duct stones after endoscopic retrograde cholangiopancreatography (ERCP) lithotomy combined with endoscopic retrograde biliary drainage (ERBD), and to provide clinical reference for treating patients with extrahepatic bile duct stones and preventing stone recurrence. Methods A total of 366 patients with extrahepatic bile duct stones treated by ERCP lithotomy and ERBD between April 2019 and August 2024 were enrolled and followed up. The patients were divided into a research group and a control group according to whether received ERPD. Recurrence outcomes were collected and compared between the two groups. Propensity score matching (PSM) was used to eliminate confounding bias, followed by Kaplan-Meier survival curve generation. COX regression analysis was performed to analyze the influencing factors. Results A total of 366 patients were included, with a median follow-up duration of 13.8 (6.2, 29.8) months. Thirteen cases (3.6%) developed recurrence. After PSM, the Kaplan-Meier survival curve showed the recurrence risk of the research group was significantly reduced (HR=0.092, 95%CI: 0.012-0.716, P=0.004). COX regression analysis revealed that duodenal papilla length>8 mm (HR=4.04, 95%CI: 1.13-14.45, P=0.032), stone type (HR=0.10, 95%CI: 0.01-0.85, P=0.035), and ERPD (HR=0.04, 95%CI: 0.00-0.72, P=0.029) were independent influencing factors. Conclusions ERPD is an independent protective factor against long-term recurrence of extrahepatic bile duct stones after ERCP lithotomy and ERBD. A duodenal papilla length>8 mm is an independent risk factor. Block extrahepatic bile duct stones have a lower long-term recurrence risk than silt-like stones.

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    Clinical observation on efficacy of Buzhongyiqi decoction combined with special mirabilite bag on postoperative wound pain and local effusion in patients with inguinal hernia tension-free repair
    CHENG Lin, SHEN Sheng, WANG Tan, LI Jiong, WANG Youliang, ZHOU Ming
    2026, 31 (04):  335-342.  DOI: 10.16139/j.1007-9610.2026.04.08
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    Objective To explore the effect of Buzhongyiqi decoction combined with special mirabilite bag on postoperative wound pain and local effusion in patients with inguinal hernia tension-free repair. Methods A total of 100 patients who underwent inguinal hernia tension-free repair in Dahua hospital, Xuhui District, from January 2023 to December 2025 were selected and divided into control group and research group according to the random number table method, with 50 cases in each group. The patients in the control group were treated with special mirabilite bag on the wound, and the patients in the research group were additionally administered Buzhongyiqi decoction on the basis of the control group treatment. The prescription consisted of Astragalus (30 g), Codonopsis (15 g), Fried licorice (10 g), Atractylodes (10 g), Angelica sinensis (10 g), Bupleurum (10 g), Cimicifuga (8 g), and Tangerine (6 g). The prescription was modified according to the patient’s pain severity. For patients with severe pain, Wulingzhi (10 g), Puhuang (10 g), Yanhusuo (10 g), and Motherwort (30 g) were added. The visual analogue scale (VAS) score for pain, traditional Chinese medicine (TCM) syndrome score, time to first flatus,incision healing time,hospitalization period,inflammatory indicators, local effusion,clinical efficacy and complication incidence rates were compared between the two groups after treatment. Results After treatment, the VAS scores for pain at 3, 5, and 7 days after surgery, various TCM syndrome scores, levels of inflammation indicators in the study group were significantly lower than those in the control group (P<0.05). The time to first flatus, incision healing time, and hospitalization period in the study group were shorter, the postoperative 7-day incision fluid accumulation depth was shallower, and the urine volume on the 3rd day after surgery was more, and the improvement effect of local effusion was better (P<0.05); the clinical total effective rate of the study group was 92.0%, significantly higher than that of the control group’s 64.0% (P<0.05); there was no significant difference in the complication incidence rates between the two groups (P>0.05). Conclusions Buzhongyiqi decoction combined with special mirabilite bag has significant effect on postoperative pain, effusion and other symptoms in patients with inguinal hernia tension-free repair, which can effectively prevent postoperative infection and promote postoperative recovery.

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    Review
    A stratified training pathway for endoscopic thyroidectomy based on the CIPP model: from learning curve to training curve
    SHI Yu, LI Peiheng, WANG Xueying, HUANG Jing, LUO Han
    2026, 31 (04):  343-352.  DOI: 10.16139/j.1007-9610.2026.04.09
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    Endoscopic thyroidectomy involves diverse approaches with high technical demands, and the learning curves vary significantly across different approaches. Traditional training models, which rely primarily on experiential teaching and case accumulation, are inadequate to meet the requirements of standardized, competency-oriented education. This review introduced the CIPP (Context, Input, Process, Product) evaluation model as a theoretical framework and incorporated the learning curve characteristics of various endoscopic thyroidectomy approaches to construct a stratified training pathway across four dimensions: context evaluation, input evaluation, process evaluation, and product evaluation. Based on the Dreyfus model of skill acquisition, the training process is divided into four stages: foundation, transition, competence, and proficiency. On the basis of shared endoscopic skill development, specific training modules are designed according to the distinct features of different approaches, including the transaxillary, transareolar, transoral vestibular, and bilateral axillo-breast approach (BABA). In addition, a stage-based admission and completion evaluation system is established, encompassing skill assessment, clinical performance quality, and safety indicators. This pathway attempts to translate learning curve evidence into the rationale for training curve design, facilitating a shift from experience-based accumulation to competency-based cultivation. It provides a theoretical basis and practical reference for the standardized training of surgeons specializing in endoscopic thyroidectomy.

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    Research progress in surgical treatment of lower extremity varicose veins
    YI Yuqi, CHEN shicong, PI Suyu, DENG Hongping
    2026, 31 (04):  353-360.  DOI: 10.16139/j.1007-9610.2026.04.10
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    In the treatment of varicose veins of the lower limbs, surgical procedures remain the primary method. The continuous advancement of surgical techniques has expanded the treatment methods from traditional surgery to various methods, including endovascular minimally invasive treatments and external rotary resection techniques. Among these, endovascular minimally invasive treatments are developing particularly fast, covering a variety of methods including radiofrequency, laser, microwave, electrocoagulation, foam sclerotherapy, cyanoacrylate glue embolization, and mechanochemical ablation. Each procedure has its own advantages and disadvantages. Modern treatment focuses on individualized treatment plans, and encourages the use of various techniques together to achieve minimally invasive and effective results.

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    Single-disease quality management model for colorectal cancer in general hospital
    HUANG Xiaoqian, QU Qing, ZHANG Jun, GENG Mei, BIAN Xiaolan, LI Juan, ZHAO Ren, XI Jing, ZHAO Yan, SHAO Wei, GAO Weiyi, JIN Rui
    2026, 31 (04):  361-370.  DOI: 10.16139/j.1007-9610.2026.04.11
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    In recent years, the incidence rate and mortality of colorectal cancer have continued to rise. There are significant differences in diagnosis and treatment of cancer in different regions and hospitals of different grades. The standardization and homogeneity of cancer diagnosis and treatment need to be improved. This paper explored the feasibility of a comprehensive single-disease management model for colorectal cancer through optimizing organizational structures, establishing standardized operation procedure and quality control standards, conducting comprehensive training, and enhancing information technology. Within 4 years of implementation, remarkable management outcomes have been achieved by this model. The clinical TNM staging rate of colorectal cancer has been elevated to above 99% for colorectal cancer. The proportion of costs for antineoplastic drugs among hospitalized patients decreased by 4.2 percentage points. The proportion of chemotherapy drug costs decreased by 2.1 percentage points. The proportion of costs for antineoplastic drugs within the national medical insurance drug catalogue decreased by 4.4 percentage points. This single-disease management model effectively promotes the homogenization and intelligent development of colorectal cancer diagnosis and treatment, ultimately enhancing clinical benefit for patients.

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