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    25 July 2024, Volume 29 Issue 04 Previous Issue   
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    Editorial Evolution
    Evolution and progress of hernia repair techniques in the past 30 years in China
    TANG Jianxiong, MENG Yunxiao
    2024, 29 (04):  279-284.  DOI: 10.16139/j.1007-9610.2024.04.01
    Abstract ( 41 )   HTML ( 3 )   PDF (924KB) ( 11 )  

    This article provided an overview of the basic concepts and historical development of hernias. The introduction of the concept of “tension-free hernioplasty” marked a milestone in hernia surgery, while the establishment of the concept of “abdominal domain” has propelled its development. This article introduced the introduction and promotion of hernia repair techniques in China, with a focus on discussing the stages of development for Chinese hernia surgical repair techniques including open surgery, laparoscopic surgery, robotic surgery, as well as the application and development of minimally invasive techniques. It emphasized that surgical methods should be selected based on the classification of abdominal wall hernia and the 3R(repair, reconstruction, restoration) principle for abdominal wall reconstruction. Additionally, this article explored advancements in materials science and the promotion of day surgery models.

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    Abdominal wall functional reconstruction in laparoscopic ventral and incisional hernia repair
    LI Jianwen, ZHANG Yun, YUE Fei
    2024, 29 (04):  285-291.  DOI: 10.16139/j.1007-9610.2024.04.02
    Abstract ( 31 )   HTML ( 4 )   PDF (907KB) ( 8 )  

    The treatment of ventral and incisional hernias has progressed from simple repair and reinforcement to reconstruction, restoration, and regeneration. There are Onlay, Sublay, preperitoneal, intraperitoneal repair planes, and each plane could be performed via open or laparoscopic surgery. Laparoscopic surgery mainly includes intraperitoneal onlay mesh (IPOM) and minimally invasive non-intraperitoneal mesh (MINIM) repair. Regardless of the technique applied, it is essential to follow the principles of abdominal wall functional reconstruction and minimally invasive features to demonstrate their clinical value. The core of abdominal wall functional reconstruction in laparoscopic surgery for ventral and incisional hernias could be summarized as restoring Anatomical structure, protecting Biomechanics, maintaining Compliance, and providing overall Dynamic support for the body.

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    Experts forum
    Surgical treatment strategies for gastroesophageal reflux disease
    CHEN Shuang, HUANG Enmin, ZHOU Taicheng
    2024, 29 (04):  292-295.  DOI: 10.16139/j.1007-9610.2024.04.03
    Abstract ( 39 )   HTML ( 2 )   PDF (990KB) ( 8 )  

    Gastroesophageal reflux disease (GERD) is a common digestive disorder with a global prevalence of approximately 13%. The primary surgical options include the 360° Nissen fundoplication, 270° Toupet fundoplication, and 180° Dor fundoplication. While the Nissen procedure demonstrates superior long-term outcomes compared to the other methods, it is associated with a higher incidence of postoperative dysphagia. Surgical decisions should be individualized based on esophageal motility and pH monitoring. The surgery not only aims to repair anatomical structures, but also to restore function, including the length of the abdominal esophagus and the angulation between the crura diaphragm and the spine. Reconstruction of the gastroesophageal valve and the phrenoesophageal fascia is crucial for optimizing surgical outcomes and preventing postoperative complications. Given the physiological and psychological changes associated with GERD, personalized treatment is essential for improving symptoms and enhancing quality of life.

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    Diagnosis and treatment of diseases with diaphragmatic anatomic abnormalities
    JI Zhenling
    2024, 29 (04):  296-299.  DOI: 10.16139/j.1007-9610.2024.04.04
    Abstract ( 33 )   HTML ( 2 )   PDF (3148KB) ( 9 )  

    Hiatal hernia, para-hiatal hernia, diaphragmatic hernia, diaphragmatic agenesis and diaphragmatic eventration are the main types of the diseases with diaphragmatic anatomic abnormalities. Benign and malignant tumors of the diaphragm are not discussed in this paper. Caused by the lack of knowledge about these diseases, improper imaging, clinical diagnosis is often confusing. Based on the literatures and our own experience, this paper proposes the concept of “diseases with diaphragmatic anatomic abnormalities”. The purpose is to summarize these diseases, and briefly describe the treatment methods, and to help strengthen the understanding and treatment of such diseases.

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    Innovation in the era of big data: advancing abdominal wall mechanics research through machine learning and artificial intelligence
    MAO Minghuan, YANG Binze, PENG Xueqiang, LI Hangyu
    2024, 29 (04):  300-303.  DOI: 10.16139/j.1007-9610.2024.04.05
    Abstract ( 29 )   HTML ( 2 )   PDF (911KB) ( 5 )  

    Research in abdominal wall mechanics is progressively overcoming the limitations of traditional assessment methods with the application of machine learning and artificial intelligence technologies. By leveraging deep learning algorithms and big data analytics, precise mechanical and predictive models are being established to analyze the stress distribution in abdominal wall muscles under various conditions, facilitating the development of personalized treatment strategies. This approach not only aids in optimizing hernia repair strategies and reducing recurrence risks, but also has the potential to improve patient outcomes. Looking ahead, the continued integration of multidimensional data will further drive systematic research and clinical application in the field of abdominal wall mechanics.

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    Opportunities and challenges for high-quality development of day surgery services in hernia and abdominal wall surgery
    LIU Yuchen, WANG Minggang
    2024, 29 (04):  304-310.  DOI: 10.16139/j.1007-9610.2024.04.06
    Abstract ( 25 )   HTML ( 2 )   PDF (894KB) ( 4 )  

    The number of day surgeries in hernia and abdominal wall surgery has grown rapidly, and basic requirements need to be put forward for organizational structure, institutional norms, operational management, quality control, and all under the supervision of health administrative departments to ensure quality and safety. Currently, the Expert Committee on Day Surgery for Abdominal Wall Surgery, in collaboration with multiple departments, has developed and updated the expert consensus on standards for hernia and abdominal wall day surgery. The development of day surgery services in this field faces both opportunities and challenges. Opportunities include advancements in medical technology, the spread of minimally invasive surgery, and the growing demand for rapid recovery. Challenges involve the rational allocation of medical resources, the cultivation of professional talents, and the establishment of technical standards. Ensuring medical quality and safety while improving service efficiency remains a significant challenge.

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    Treatment of primary abdominal wall tumors via minimally invasive surgery
    HAN Haifeng, LU Jinghui
    2024, 29 (04):  311-315.  DOI: 10.16139/j.1007-9610.2024.04.07
    Abstract ( 23 )   HTML ( 2 )   PDF (978KB) ( 6 )  

    Primary abdominal wall tumors constitute approximately 10% of the total spectrum of soft tissue tumors. Based on their biological characteristics, these tumors can be classified into three distinct categories: benign, malignant, and borderline. Different subtypes of abdominal wall tumors exhibit significant heterogeneity in clinical manifestations, pathological features, and prognostic outcomes. A comprehensive preoperative evaluation by a multidisciplinary team, incorporating both pathological and radiological assessments, is indispensable for tailoring individualized treatment strategies. In recent years, laparoscopic surgery has emerged as a promising modality for resection and reconstruction of abdominal wall tumors, particularly those deep-seated or intramural. Compared with conventional open surgery, laparoscopic surgery offers several advantages, including reduced tissue trauma, precise tumor resection, lower rate of postoperative complications, faster recovery, and enhanced cosmetic results. Nevertheless, the long-term efficacy and the breadth of applications of laparoscopic surgery in the management of abdominal wall tumors warrant further investigation through rigorous clinical trials.

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    Consensus and guideline
    Interpretation of the updated international guidelines for groin hernia management (2023)
    XU Jing, ZHUANG Qiulin, DONG Ruizhao, YANG Ziang
    2024, 29 (04):  316-322.  DOI: 10.16139/j.1007-9610.2024.04.08
    Abstract ( 77 )   HTML ( 7 )   PDF (966KB) ( 28 )  

    Since the International guidelines for groin hernia management were published in 2018, many new evidences have been published. In October 2023, the HerniaSurge Group published Update of the international HerniaSurge guidelines for groin hernia management. It updated eight chapters of the last guidelines, proposed 20 key questions, and 39 new statements and 32 recommendations, of which 16 were strong recommendations. This article combined clinical concerns to sort out and interpret the updated version.

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    Original article
    Lateral approach single-incision laparoscopic totally extraperitoneal inguinal hernia repair: a report of 110 cases
    ZHANG Yizhong, TANG Rui, WANG Tingfeng, SI Xianke, YE Lebin, LIU Nan, XIANG Shijun, WU Weidong
    2024, 29 (04):  323-328.  DOI: 10.16139/j.1007-9610.2024.04.09
    Abstract ( 96 )   HTML ( 3 )   PDF (11620KB) ( 17 )  

    Objective To present the initial practice of a novel procedure for the surgical treatment of inguinal hernia -“lateral approach single-incision laparoscopic totally extraperitoneal (L-SILTEP) repair” in certain specific situations. Methods The clinical data of 110 inguinal hernia patients who underwent L-SILTEP in the First Affiliated Hospital of Ningbo University, Shanghai General Hospital affiliated to Shanghai Jiao Tong University School of Medicine, and Shanghai East Hospital affiliated to Tongji University from June 2021 to March 2024 were collected retrospectively. Patients′ demographics, surgical details, length of hospital stay, and postoperative outcomes were analyzed respectively. Results All surgeries were completed successfully and there was no conversion. The median surgical time was 55 (41.25, 70) mins and the intraoperative blood loss was 5 (2,10) mL. In surgery, inferior epigastric artery injury occurred in 5 cases (4.5%) and spermatic cord injury occurred in 1 case (0.9%). The mean visual analog scale (VAS) scores pain assessment at 6, 24, and 48 h after surgery were 3.0 ± 0.8, 1.9 ± 0.7 and 1.1 ± 0.4, respectively. The duration of hospital stay was (3.3 ± 0.7) days. The most common postoperative complication was seroma, which occurred in 9 cases (8.2%). Additionally, extraperitoneal hematoma occurred in 1 case (0.9%) and scrotum effusion in 1 case (0.9%). Conclusions Generally, L-SILTEP is safe, feasible and effective. However,due to its advanced technique-demand, the application of L-SILTEP should be patient-specific and surgeon-specific. The successful implementation of this surgical procedure necessitates extensive training and meticulous attention to the surgical details.

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    Preliminary evaluation of surgical treatment for postpartum diastasis recti
    LIU Lu, ZHU Xiaoqiang, LIU Nan, LIU Jiajie, TANG Rui
    2024, 29 (04):  329-335.  DOI: 10.16139/j.1007-9610.2024.04.10
    Abstract ( 35 )   HTML ( 4 )   PDF (14534KB) ( 15 )  

    Objective To evaluate the clinical efficacy, safety and the postoperative functional improvement of the surgical treatment for postpartum diastasis recti (PDR). Methods A retrospective study was conducted on the patients with PDR who underwent surgical treatment in Department of Hernia and Abdominal Wall Surgery, Shanghai East Hospital, Tongji University from November 2018 to October 2023. The patients’demography, operation data, postoperative complications, recurrence and functional evaluation before and after surgery were analyzed. Results A total of 39 cases were included. Open surgery was performed in 21 cases, laparoscopic surgery in 17 cases, and hybrid surgery in 1 case. On the basis of linear alba reconstruction (LAR), 26 cases were additionally repaired with Sublay mesh, 9 with Onlay, and 1 with intraperitoneal onlay mesh (IPOM); the other 3 cases were only performed with LAR. The follow-up ranged 6-45 months, and the completion rate was 92.3%. During the follow-up, no recurrence was observed, and the overall complication rate was 20.5%, including 1 case with delayed wound healing, 2 cases with seroma, and 5 cases with skin disorders in paraumbilical and subumbilical area. There were significant changes of European Registry for abdominal wall hernias quality of life (EuraHS QoL) score and Oswestry disability index (ODI) after operation, indicating significant improvement in QoL and lower back pain. The inter-recti distance(IRD) of the patients undergoing laparoscopic surgery was less than that of the patients undergoing open surgery (median 4.0 cm vs. 4.5 cm), and the duration of hospital stay of the patients undergoing laparoscopic surgery was shorter than that of open surgery (median 7 days vs. 9 days). Conclusions In general, the surgical treatment of PDR is safe and effective, and it can not only correct the separation, but also improve QoL and lower back pain of the patients. Tailored surgical procedures should be selected for patients with different conditions.

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    Correlationship between total proteins SUMOylation and papillary thyroid carcinoma in males
    WU Qiao, LIU Wei, ZHENG Jiaojiao, WANG Cong, AI Zhilong
    2024, 29 (04):  336-344.  DOI: 10.16139/j.1007-9610.2024.04.11
    Abstract ( 36 )   HTML ( 2 )   PDF (8797KB) ( 6 )  

    Objective To investigate the relationship between protein SUMOylation level and the prognosis of papillary thyroid carcinoma(PTC) in males. Methods Protein SUMOylation levels in PTC was analyzed by bioinformatics based on GTEx and TCGA databases and validated by immunohistochemical staining and Western blotting in our clinical pairs specimens. The mRNA expression of the protein SUMOylation associated genes were measured by fluorescent quantitative real-time polymerase chain reaction (qRT-PCR) in surgical pairs specimens. Results The expression level of SUMOylation in the tumor tissues of PTC showed an elevated trend(P<0.05), and was associated with poor prognosis of the patients by TCGA and GTEx databases analysis(P=0.021). In the clinical samples of our hospital, it was verified that the level of SUMOylation in tumor tissues was higher than that of the paired non-tumor tissues(P<0.05). However, qRT-PCR showed no significant changes in the transcriptional level of the protein SUMOylation associated genes in most cases. Conclusions Protein SUMOylation in thyroid tumor tissues were higher than that in paired non-tumor tissues, and the higher SUMOylation levels levels in tumor tissues were, the shorter overall survival time of the patients was.

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    Size discrepancy between ultrasonic and pathological measurement of solitary cN0M0 papillary thyroid microcarcinoma
    REN Yujie, LI Yujiang, ZENG Zheng, WANG Jianhua, DING Wenbo, WU Xinping, LIU Chao, XU Shuhang
    2024, 29 (04):  345-350.  DOI: 10.16139/j.1007-9610.2024.04.12
    Abstract ( 24 )   HTML ( 4 )   PDF (993KB) ( 6 )  

    Objective To compare the size discrepancy between ultrasonic and pathological measurement of solitary cN0M0 papillary thyroid microcarcinoma (PTMC), and to explore their correlation with lymph node metastasis. Methods From April 2021 to January 2022, 234 patients with solitary cN0M0 PTMC who received thyroid lobectomy or total thyroidectomy in the Department of Thyroid and Breast Surgery of Nanjing University of Chinese Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine were analyzed retrospectively. The size discrepancy between ultrasonic and pathological measurement were compared, and the risk factors of central lymph node metastasis were analyzed. Results The mean of maximum diameter of PTMC measured by ultrasound was 6.8 (range 5.6 to 8.4) mm, which was significantly bigger than that measured by pathology 5.0 (range 4.0 to 7.0) mm (P=0.000). Of them, 37.2% of the tumor size measured by ultrasound is consistent with pathology, 61.1% of the tumor size measured by ultrasound is bigger than that measured by pathology, and only 1.7% of the tumor size measured by ultrasound is smaller than that measured by pathology. There was a linear correlation between the diameter measured by ultrasound and pathology. And the regression equation can be expressed as: pathological diameter =0.799 × ultrasonic diameter -0.221. In addition, 28.6% patients had central lymph node metastasis. Multivariate Logistic regression analysis showed that the diameter measured by pathology is a risk factor for central lymph node metastasis in patients (OR=17.845, 95%CI: 2.507-127.025, P=0.004), and the cutoff value is 5.5 mm which corresponded to the diameter measured by ultrasound as 7.2 mm. Conclusions The sizes of solitary cN0M0 PTMC measured by ultrasound and pathology are different but also correlated. PMTC with pathological diameter >5.5 mm with its corresponding ultrasonic diameter as 7.2 mm indicated an increased risk of central lymph node metastasis.

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    Analysis of the efficacy and influence factors for treatment of primary hepatocellular carcinoma by Huachansu tablets combined with transarterial chemoembolization
    CHENG Chienshan, ZHANG Tao, WU Junwei, GAO Huifeng, CHEN Jingxian, MENG Zhiqiang
    2024, 29 (04):  351-357.  DOI: 10.16139/j.1007-9610.2024.04.13
    Abstract ( 26 )   HTML ( 2 )   PDF (967KB) ( 7 )  

    Objective To evaluate the efficacy of Huachansu tablets combined with transarterial chemoembolization (TACE) for treatment of primary hepatocellular carcinoma (HCC) and prognostic influence factors. Methods One hundred and eight patients with HCC were recruited according to the inclusion and exclusion criteria. Patients were randomly divided into treatment group and control group. The treatment group was treated with Huachansu tablets combined with TACE, and the control group was treated with TACE alone, with overall survival time (OS) and progression-free survival time (PFS) as the evaluation indexes. The COX regression analysis was used to evaluate the survival and prognostic effects and their influence factors in both groups. Results A total of 108 HCC patients were enrolled. The OS was 13.5 months in treatment group and 9.2 months in control group; the PFS was 6.8 months in treatment group and 5.3 months in control group, and the differences were significant statistically (all P<0.05). Multivariate COX regression analysis showed that Child-Pugh grade and cirrhosis were the independent risk factors for PFS in HCC patients. Child-Pugh grade were the independent risk factors for OS in HCC patients. ALBI is a protective factor for OS in HCC patients. Conclusions The treatment of HCC by Huachansu tablets combined with TACE can delay the progression of HCC and prolong PFS and OS of the patients with HCC. Child-Pugh grade, cirrhosis status, and ALBI were important factors affecting the prognosis of the patients with HCC.

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    Review
    Progress in research of the risk factors of lymph node metastasis in T1 stage colorectal cancer
    CHEN Fangqian, FENG Wenqing, ZHAO Jingkun, ZONG Yaping, LU Aiguo
    2024, 29 (04):  358-364.  DOI: 10.16139/j.1007-9610.2024.04.14
    Abstract ( 28 )   HTML ( 3 )   PDF (985KB) ( 5 )  

    Colorectal cancer is one of the common malignant tumors of the digestive tract. With the popularization of screening methods and advancement of endoscopic technology, an increasing number of T1 stage colorectal cancers can be discovered. Accurately predicting lymph node metastasis risk is significantly important for guiding clinical treatment decisions, reducing complications and mortality. Current research on risk factors for lymph node metastasis in T1 stage colorectal cancer covers multiple aspects including clinical pathological features, molecular phenotypes and genetic characteristics. Some studies have built prediction models by integrating these factors, which show higher sensitivity, specificity and accuracy compared to current clinical guidelines. These models provide valuable experience for clinical practice.

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    Advances in research of pancreaticobiliary maljunction-associated gallbladder cancer
    MA Yubo, LI Qi, ZHANG Dong, GENG Zhimin
    2024, 29 (04):  365-369.  DOI: 10.16139/j.1007-9610.2024.04.15
    Abstract ( 27 )   HTML ( 2 )   PDF (879KB) ( 3 )  

    Pancreatobiliary maljunction (PBM) represents a congenital anatomical abnormality of the pancreaticobiliary ductal system, frequently predisposing individuals to recurrent cholangitis and pancreatitis. Accumulating evidence indicates that PBM is a precancerous lesion, and PBM plays an important role in the development and progression of gallbladder cancer (GBC). GBC arising from PBM is designated as PBM-associated GBC. Consequently, early diagnosis and treatment of PBM is paramount in mitigating the risk of GBC. This review outlined the epidemiology and advancements in the diagnosis and management of PBM, along with the clinical features, underlying mechanisms, and therapeutic progressions pertaining to PBM-associated GBC, in order to underscore the clinical significance of early intervention in PBM, so as to reduce the incidence of PBM-associated GBC.

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