Abstract:

Objective To investigate estrogen as one of risk factors in women with gallstone in Xinjiang. Methods Estradiol, luteinizing hormone(LH), follicle-stimulating hormone(FSH), testosterone, progesterone, and prolactin in 204 women with gallstone were compared with those in 204 control patients without gallstone. Results There were no statistically significant differences in LH, FSH, testosterone, progesterone and prolactin levels between Xinjiang female patients with gallstone and the patients in control group and between female patients with single stone and those with multiple stones. Estradiol level increased statistically significant both premenopausal women and postmenopausal women when compared with controls women. Higher estradiol level was found in female patients of multiple gallstones compared with that in female patients of single gallstone with statistically significant difference. Conclusions There was increase in serum estrogen of premenopausal and postmenopausal women combined with the higher estrogen level in women with multiple gallstones than those with single gallstone, which indicated the increasing in serum estrogen may be risk factor for gallstone disease and the pathogenesis of gallstone disease.

Key words: Female estrogen, Gallstone disease, Risk factor, Pathogeneses