Comprehensive diagnosis and treatment strategy for functional pancreas neuroendocrine neoplasm： a report of 3 cases

doi:10.16139/j.1007-9610.2025.05.10

Abstract

Abstract:

Functional neuroendocrine neoplasm, which secrete hormones and lead to diverse clinical symptoms, pose significant challenges in diagnosis and treatment. Early identification and standardized management are crucial for improving patient prognosis. This article summarized three clinically relatively common cases of Functional pancreatic neuroendocrine neoplasm (F-pNENs), focusing on analyzing their diagnostic key points and standardized therapeutic pathways. It aimed to provide reference for early clinical identification of rare tumors and improvement of standardized multidisciplinary diagnosis and treatment as well as personalized treatment strategies.

Key words: Neuroendocrine neoplasm, Functional pancreatic neuroendocrine neoplasm (F-pNEN), Glucagonoma, Insulinoma, Vasoactive intestinal peptide tumor (VIPoma)

CLC Number:

R735.9

JI Bei, SHANG Zhengye, TUO Biguang, LIU Xuemei. Comprehensive diagnosis and treatment strategy for functional pancreas neuroendocrine neoplasm： a report of 3 cases[J]. Journal of Surgery Concepts & Practice, 2025, 30(05): 438-443.

Figures/Tables 6

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References 12

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Time	Blood glucose （mmol/L）	Serum insulin （μIU/mL）	Serum C-peptide （nmol/L）
Fasting	9.5	25	2.2
1-hour postprandial	16.13	65	3.8
2-hour postprandial	14.26	50	3.0
3-hour postprandial	12.91	40	2.5

Time	Blood glucose （mmol/L）	Serum insulin （μIU/mL）	Serum C-peptide （nmol/L）
Fasting	2.64	65	2.8
1-hour postprandial	7.56	118	3.9
2-hour postprandial	5.46	97	3.2
3-hour postprandial	3.82	73	3.0