Objective To study the prognostic value of preoperative white blood cell (WBC) count in patients with hepatocellular carcinoma(HCC) beyond Milan criteria after hepatic resection. Methods Clinical data of 237 patients with HCC beyond Milan criteria from Tianjin Medical University Cancer Hospital who underwent hepatectomy from June 2007 to December 2013 were retrospectively studied. The cut-off value of WBC count was determined by receiver operating characteristic curve, which was used to divide the patients in two groups. Survival curves were formed with Kaplan-Meier method and were analyzed using Log-Rank test. Cox proportional hazards model was developed to identify the risk factors of survival. Results WBC count 6.0 ×109/L was the cut-off point between two groups. The median survival time of lower WBC count group and higher WBC count group were 53.4 and 27.6 months, respectively (P=0.002). The median recurrence-free survival of lower WBC count group and higher WBC count group were 20.7 and 12.2 months, respectively(P=0.029). The statistical differences in both survival time and recurrence-free survival remained between two groups after match analysis. Conclusions Preoperative WBC count might predict the prognosis of HCC patients beyond Milan criteria after hepatic resection.
HOU Zhenyu, KONG Yinlong, ZHANG Yongqiang, ZHU Keyun, YANG Xuejiao, CHEN Ping, LI Huikai, CUI Yunlong, SONG Tianqiang, LI Qiang, ZHANG Ti
. Preoperative white blood cell count predicts prognosis in patients with hepatocellular carcinoma beyond Milan criteria after hepatic resection[J]. Journal of Surgery Concepts & Practice, 2018
, 23(04)
: 358
-362
.
DOI: 10.16139/j.1007-9610.2018.04.017
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