Journal of Surgery Concepts & Practice ›› 2018, Vol. 23 ›› Issue (04): 358-362.doi: 10.16139/j.1007-9610.2018.04.017

• Original article • Previous Articles     Next Articles

Preoperative white blood cell count predicts prognosis in patients with hepatocellular carcinoma beyond Milan criteria after hepatic resection

HOU Zhenyu1, KONG Yinlong1, ZHANG Yongqiang2, ZHU Keyun1, YANG Xuejiao1, CHEN Ping1, LI Huikai1, CUI Yunlong1, SONG Tianqiang1, LI Qiang1, ZHANG Ti1   

  1. 1. Department of Hepatobiliary Cancer, Tianjin Medical University Cancer Hospital, Tianjin Key Laboratory of Cancer Prevention and Therapy, National Cancer Clinical Research Cente, Tianjin 300060, China;
    2. Department of General Surgery, Tianjin Xiqing Hospital, Tianjin 300380, China
  • Received:2018-03-21 Online:2018-07-25 Published:2020-07-25

Abstract: Objective To study the prognostic value of preoperative white blood cell (WBC) count in patients with hepatocellular carcinoma(HCC) beyond Milan criteria after hepatic resection. Methods Clinical data of 237 patients with HCC beyond Milan criteria from Tianjin Medical University Cancer Hospital who underwent hepatectomy from June 2007 to December 2013 were retrospectively studied. The cut-off value of WBC count was determined by receiver operating characteristic curve, which was used to divide the patients in two groups. Survival curves were formed with Kaplan-Meier method and were analyzed using Log-Rank test. Cox proportional hazards model was developed to identify the risk factors of survival. Results WBC count 6.0 ×109/L was the cut-off point between two groups. The median survival time of lower WBC count group and higher WBC count group were 53.4 and 27.6 months, respectively (P=0.002). The median recurrence-free survival of lower WBC count group and higher WBC count group were 20.7 and 12.2 months, respectively(P=0.029). The statistical differences in both survival time and recurrence-free survival remained between two groups after match analysis. Conclusions Preoperative WBC count might predict the prognosis of HCC patients beyond Milan criteria after hepatic resection.

Key words: Hepatocellular carcinoma, Milan criteria, Hepatectomy, White blood cell, Prognosis

CLC Number: