Journal of Surgery Concepts & Practice >
Challenges and opportunities in the diagnosis and treatment of thyroid carcinoma in children and young adolescents
Received date: 2023-10-16
Online published: 2024-03-04
Thyroid carcinoma in children and young adolescent is a special type of thyroid carcinoma, which has received more and more attention. In recent years, confusion and difficulties continue to emerge in understanding the disease. This article reviewed these clinical challenges and summarized recent research progress at home and abroad, with a view to identifying valuable opportunities to improve the diagnosis and treatment of thyroid carcinoma in children and young adolescents.
Key words： Children; Young adolescent; Thyroid carcinoma
WANG Zhuoying , SHI Yuan , GUO Kai , QIAN Kai . Challenges and opportunities in the diagnosis and treatment of thyroid carcinoma in children and young adolescents[J]. Journal of Surgery Concepts & Practice, 2023 , 28(06) : 496 -500 . DOI: 10.16139/j.1007-9610.2023.06.02
| [1] | 王卓颖, 史苑, 郭凯, 等. 青少年分化型甲状腺癌的诊治:从陌生到规范[J]. 外科理论与实践, 2021, 26(6):497-499. |
| WANG Z Y, SHI Y, GUO K, et al. Diagnosis and treatment of differentiated thyroid cancer in adolescents: from unfamiliarity to standardization[J]. J Surg Concepts Pract, 2021, 26(6):497-499. | |
| [2] | GUO K, QIAN K, SHI Y, et al. Clinical and molecular characterizations of papillary thyroid cancer in children and young adults: a multicenter retrospective study[J]. Thyroid, 2021, 31(11):1693-1706. |
| [3] | VAN DE BERG D J, KUIJPERS A M J, ENGELSMAN A F, et al. Long-term oncological outcomes of papillary thyroid cancer and follicular thyroid cancer in children: a nationwide population-based study[J]. Front Endocrinol (Lausanne), 2022, 13:899506. |
| [4] | WEBER T, HUMMEL R, VORL?NDER C, et al. Thyroid surgery in children and adolescents: results from a multi-institutional German and Austrian database[J]. Br J Surg, 2023, 110(12):1808-1814. |
| [5] | 中国临床肿瘤学会. 中国临床肿瘤学会甲状腺髓样癌诊疗指南[M]. 北京: 人民卫生出版社, 2022. |
| Chinese Society of Clinical Oncology. Diagnosis and treatment guidelines for medullary thyroid carcinoma of the Chinese Society of Clinical Oncology[M]. Beijing People's Health Publishing House, 2022. | |
| [6] | HALADA S, BARAN J A, BAUER A J, et al. Clinicopathologic characteristics of pediatric follicular variant of papillary thyroid carcinoma subtypes: a retrospective cohort study[J]. Thyroid, 2022, 32(11):1353-1361. |
| [7] | KIM S Y, YUN H J, CHANG H, et al. Aggressiveness of differentiated thyroid carcinoma in pediatric patients younger than 16 years: a propensity score-matched analysis[J]. Front Oncol, 2022, 12:872130. |
| [8] | THIESMEYER J W, EGAN C E, GREENBERG J A, et al. Prepubertal children with papillary thyroid carcinoma present with more invasive disease than adolescents and young adults[J]. Thyroid, 2023, 33(2):214-222. |
| [9] | SUGINO K, NAGAHAMA M, KITAGAWA W, et al. Cutoff age between pediatric and adult thyroid differentiated cancer: is 18 years old appropriate?[J]. Thyroid, 2022, 32(2):145-152. |
| [10] | DA SILVA BREDER J R A, ALVES P A G, ARAúJO M L, et al. Puberty and sex in pediatric thyroid cancer: could expression of estrogen and progesterone receptors affect prognosis?[J]. Eur Thyroid J, 2022, 11(2):e210090. |
| [11] | STOSIC A, FULIGNI F, ANDERSON N D, et al. Diverse oncogenic fusions and distinct gene expression patterns define the genomic landscape of pediatric papillary thyroid carcinoma[J]. Cancer Res, 2021, 81(22):5625-5637. |
| [12] | NIES M, VASSILOPOULOU-SELLIN R, BASSETT R L, et al. Distant metastases from childhood differentiated thyroid carcinoma: clinical course and mutational landscape[J]. J Clin Endocrinol Metab, 2021, 106(4):e1683-e1697. |
| [13] | LEE Y A, LEE H, IM S W, et al. NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake[J]. J Clin Invest, 2021, 131(18):e144847. |
| [14] | LI H, HAN R, MENG L, et al. Nodal metastases associa-ted with fusion oncogenes are age dependent in young adult patients with thyroid cancer[J]. J Clin Endocrinol Metab, 2023, 109(1):143-150. |
| [15] | XING Z, QIU Y, ZHU J, et al. Diagnostic performance of adult-based ultrasound risk stratification systems in pe-diatric thyroid nodules: a systematic review and meta-analysis[J]. Front Endocrinol (Lausanne), 2023, 14:1187935. |
| [16] | TULI G, MUNARIN J, SCOLLO M, et al. Evaluation of the efficacy of EU-TIRADS and ACR-TIRADS in risk stratification of pediatric patients with thyroid nodules[J]. Front Endocrinol (Lausanne), 2022, 13:1041464. |
| [17] | Ren P Y, Liu J, Xue S, et al. Pediatric differentiated thyroid carcinoma: the clinicopathological features and the coexistence of Hashimoto's thyroiditis[J]. Asian J Surg, 2019, 42(1):112-119. |
| [18] | WON J H, LEE J Y, HONG H S, et al. Thyroid nodules and cancer in children and adolescents affected by Hashimoto's thyroiditis[J]. Br J Radiol, 2018, 91(1087):20180014. |
| [19] | YANG J, PAGE L C, WAGNER L, et al. Thyroid nodules on ultrasound in children and young adults: comparison of diagnostic performance of radiologists' impressions, ACR TI-RADS, and a deep learning algorithm[J]. Am J Roentgenol, 2023, 220(3):408-417. |
| [20] | VAN ROOIJEN J J, VAN TROTSENBURG A S P, VAN DE BERG D J, et al. Complications after thyroidectomy in children: lymph node dissection is a risk factor for permanent hypocalcemia[J]. Front Endocrinol (Lausanne), 2021, 12:717769. |
| [21] | MAKSIMOSKI M, BAUER A J, KAZAHAYA K, et al. Outcomes in pediatric thyroidectomy: results from a multinational, multi-institutional database[J]. Otolaryngol Head Neck Surg, 2022, 167(5):869-876. |
| [22] | WU S Y, CHIANG Y J, FISHER S B, et al. Risks of hypoparathyroidism after total thyroidectomy in children: a 21-year experience in a high-volume cancer center[J]. World J Surg, 2020, 44(2):442-451. |
| [23] | ZOBEL M J, LONG R, GOSNELL J, et al. Postoperative hypoparathyroidism after total thyroidectomy in children[J]. J Surg Res, 2020, 252:63-68. |
| [24] | SPINELLI C, GHIONZOLI M, BERTOCCHINI A, et al. Factors associated with postoperative hypocalcemia following thyroidectomy in childhood[J]. Pediatr Blood Cancer, 2022, 69(8):e29576. |
| [25] | DEKKER B L, MULLER KOBOLD A C, BROUWERS A H, et al. Bone mineral density in adult survivors of pediatric differentiated thyroid carcinoma: a longitudinal follow-up study[J]. Thyroid, 2021, 31(11):1707-1714. |
| [26] | 中国临床肿瘤学会核医学专家委员会, 中国临床肿瘤学会甲状腺癌专家委员会, 中国医疗保健国际交流促进会甲状腺疾病专业委员会, 等. 儿童及青少年分化型甲状腺癌核医学诊治中国专家共识(2022年版)[J]. 中国癌症杂志, 2022, 32(5):451-468. |
| The Nuclear Medicine Expert Committee of the Chinese Society of Clinical Oncology, The Thyroid Cancer Expert Committee of the Chinese Society of Clinical Oncology, The Thyroid Disease Professional Committee of the China Association for International Exchange and Promotion of Healthcare, et al. Expert consensus on management of differentiated thyroid carcinoma in children and adolescents (2022 edition)[J]. China Oncol, 2022, 32(5):451-468. | |
| [27] | KUMAR P, DAMLE N A, BAL C. Radioiodine therapy in pediatric differentiated thyroid cancer: dosimetry, clinical care, and future challenges[J]. Clin Nucl Med, 2023, 48(2):158-167. |
| [28] | BOJARSKY M, BARAN J A, HALADA S, et al. Outcomes of ATA low-risk pediatric thyroid cancer patients not treated with radioactive iodine therapy[J]. J Clin Endocrinol Metab, 2023, 108(12):3338-3344. |
| [29] | PASQUAL E, SCHONFELD S, MORTON L M, et al. Association between radioactive iodine treatment for pedia-tric and young adulthood differentiated thyroid cancer and risk of second primary malignancies[J]. J Clin Oncol, 2022, 40(13):1439-1449. |
| [30] | LEBBINK C A, VAN SANTEN H M, DANEMAN A, et al. Does ultrasound really contribute to detection of residual/recurrent disease after pediatric thyroidectomy? Preliminary data supporting a "thyroglobulin-first" approach[J]. Thyroid, 2023, 33(5):645-649. |
| [31] | MAJEED A K, SATAPATHY S, BALLAL S, et al. Dynamic risk stratification for predicting long-term outcomes in pediatric differentiated thyroid cancers[J]. J Clin Endocrinol Metab, 2023, 108(6):e208-e215. |
| [32] | REDLICH A, LUSTER M, LORENZ K, et al. Age, American Thyroid Association Risk Group, and response to therapy are prognostic factors in children with differentiated thyroid cancer[J]. J Clin Endocrinol Metab, 2022, 107(1):e165-e177. |
| [33] | WIRTH L J, SHERMAN E, ROBINSON B, et al. Efficacy of selpercatinib in RET-altered thyroid cancers[J]. N Engl J Med, 2020, 383(9):825-835. |
| [34] | HONG D S, DUBOIS S G, KUMMAR S, et al. Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials[J]. Lancet Oncol, 2020, 21(4):531-540. |
| [35] | WAGUESPACK S G, TEWARI S O, BUSAIDY N L, et al. Larotrectinib before initial radioactive iodine therapy in pediatric TRK fusion-positive papillary thyroid carcinoma: time to reconsider the treatment paradigm for distantly metastatic disease?[J]. JCO Precis Oncol, 2022, 6:e2100467. |
| [36] | CHEN D Q, ZHOU E Q, CHEN H F, et al. Deciphering pathological behavior of pediatric medullary thyroid cancer from single-cell perspective[J]. PeerJ, 2023, 11:e15546. |
| [37] | GOLDFARB M, FRANCO A T. Survivorship, quality of life, and transition to adult care for pediatric and adolescent thyroid cancer survivors[J]. Thyroid, 2022, 32(12):1471-1476. |
| [38] | PEREZ M N, HALADA S, ISAZA A, et al. Health-related quality of life at diagnosis for pediatric thyroid cancer patients[J]. J Clin Endocrinol Metab, 2023, 108(5):e169-e177. |
/
| 〈 |
|
〉 |
