组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2015, Vol. 11 ›› Issue (5): 335-338.doi: 10.3969/j.issn.1673-0364.2015.05.013

• 综述 • 上一篇    下一篇

瘢痕疙瘩浸润性生长机制的研究进展

陈亚红，武晓莉   

  1. 上海交通大学医学院附属第九人民医院整复外科
  • 发布日期:2020-07-23

Research Advance in Mechanism of Keloids＇ Invasive Growth

CHEN Yahong, WU Xiaoli   

  1. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People＇s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China）
  • Published:2020-07-23

摘要： 瘢痕疙瘩(Keloid)自发或继发于皮肤损伤,以细胞外基质(尤其是胶原)的异常沉积为特征,是人类特有的病理现象。瘢痕疙瘩具有超过原始损伤边界,向周围正常组织浸润性生长的特性,单纯的注射、手术切除、激光或放射等治疗后均易复发,被认为是一种皮肤的“良性肿瘤”。我们就近几年来瘢痕疙瘩浸润性生长机制的研究进展进行综述。

关键词: 瘢痕疙瘩, 浸润性生长, 干细胞, 炎症, 微环境

Abstract: Keloid is characterised by an abnormal deposition of extracellular matrix components （collagen in particular） unique to human being, which is usually triggered by skin trauma. It. Keloid is similar to benign tumor in its biological behaviors such as aggressive growth beyond the original boundary of skin injury and invasion into normal tissue. Keloid rarely regresses, recurs at a high rate after therapies such as surgical excision, intralesional steroid injection, chemotherapy and radiotherapy. In this paper, the updated findings of molecular of keloids＇ invasive growth were reviewed.

Key words: Keloid, Invasive growth, Stem cell, Inflammation, Microenvironment

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