组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2019, Vol. 15 ›› Issue (5): 362-367.doi: 10.3969/j.issn.1673-0364.2019.05.014

• 综述 • 上一篇    下一篇

组织工程心肌补片研究进展

谭瑶，付炜   

  1. 上海交通大学医学院附属上海儿童医学中心转化医学研究所；上海交通大学医学院附属上海儿童医学中心胸心外科；上海市组织工程重点实验室
  • 收稿日期:2019-07-24 修回日期:2019-08-16 出版日期:2019-10-20 发布日期:2019-10-20
  • 作者简介:付炜(E-mail:fuweizhulu@163.com)。

Research Progress of Tissue Engineering Myocardial Patch

TAN Yao,FU Wei   

  1. Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine; Department of Pediatric Cardiothoracic Surgery, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine;Shanghai Key Laboratory of Tissue Engineering
  • Received:2019-07-24 Revised:2019-08-16 Online:2019-10-20 Published:2019-10-20
  • Contact: 上海市浦江人才计划(18PJD031)；上海交通大学医工交叉项目(YG2016MS28)；上海交通大学医学院转化医学协同创新中心合作研究项目(TM201821)；上海交通大学医学院国际和地区联合研究项目

摘要： 心肌梗死导致的心衰是威胁人类健康的主要心血管疾病,利用干细胞结合支架材料制备的组织工程心肌补片有望成为将来治疗心肌梗死的新希望。目前,关于组织工程心肌补片的研究众多,细胞和支架材料亦多种多样。本文对可能应用于组织工程心肌补片的种子细胞来源、支架材料以及影响组织工程心肌补片存活和功能的各种因素进行综述。

关键词: 组织工程, 心肌补片, 干细胞, 支架

Abstract: Heart failure caused by myocardial infarction is the main cardiovascular disease that threatens human health.Tissue engineering myocardial patch prepared by stem cell combined with scaffold material is expected to become the hope of myocardial infarction treatment in the near future. At present, there are many researches on tissue engineering myocardial patches. The cells and scaffolds are diverse. In this paper, the various cell sources and scaffolds that may be used and various factors that influence the survival and function of tissue engineered myocardial patches were all reviewed.

Key words: Tissue engineering, Myocardial patch, Stem cell, Scaffold

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