组织工程与重建外科杂志 ›› 2019, Vol. 15 ›› Issue (6): 425-427.doi: 10.3969/j.issn.1673-0364.2019.06.013

• 综述 • 上一篇    下一篇

干细胞冷冻保护剂的研究进展

张天钰,周双白,李青峰   

  1. 上海师范大学生命科学学院;上海交通大学医学院附属第九人民医院整复外科
  • 收稿日期:2019-08-16 修回日期:2019-09-30 出版日期:2019-12-20 发布日期:2019-12-20
  • 作者简介:李青峰(E-mail:dr.liqingfeng@yahoo.com)。

Advances of Cryoprotective Agents for Stem Cells

ZHANG Tianyu,ZHOU Shuangbai,LI Qingfeng   

  1. College of Life Sciences, Shanghai Normal University; Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine
  • Received:2019-08-16 Revised:2019-09-30 Online:2019-12-20 Published:2019-12-20
  • Contact: 国家自然科学基金重点国际合作项目(81620108019);国家自然科学基金面上项目(81971848)

摘要: 干细胞具有促进组织修复与再生的作用,蕴藏着广泛的临床应用前景。低温冻存是实现干细胞长期保存的常用方法。在低温保存过程中,有效的冷冻保护剂(CPA)对于防止细胞低温损伤和保持细胞活力至关重要。本文将对干细胞冷冻保护剂的研究进展进行综述。

关键词: 干细胞, 冷冻保护剂, 冷冻损伤, 细胞活性

Abstract: Stem cell can promote tissue repair and regeneration, and has a promising potential application in clinic.Cryopreservation is a common way to achieve long-term preservation of stem cells. An effective cryoprotective agents(CPA)is vital to prevent cells from cryodamage and keep cell viability during cryopreservation process. In this paper, the recent advances in CPA for stem cells were reviewed.

Key words: Stem cells, Cryoprotective agents, Cryodamage, Cell viability

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