组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2013, Vol. 9 ›› Issue (6): 344-348.doi: 10.3969/j.issn.1673-0364.2013.06.013

• 论著 • 上一篇    下一篇

婴幼儿血管瘤标志物的研究进展

马刚，林晓曦   

  1. 上海交通大学医学院附属第九人民医院整复外科
  • 发布日期:2020-07-23

Research Progress on Markers of Infantile Hemangioma

MA Gang,LIN Xiaoxi   

  1. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine;
  • Published:2020-07-23

摘要： 婴幼儿血管瘤(IH)是最常见的儿童期良性肿瘤,具有独特的增生和自发消退的自然病程,但发病机制仍未阐明,血管瘤的标志物也缺乏特异性。目前,组织学标志物主要包括血管生成、胎盘、凋亡、缺氧、炎症、淋巴、干细胞、周细胞、肥大细胞等相关标志物;体液标志物包含血清和尿液标志物,前者主要有雌激素和VEGF等细胞因子,后者主要有bFGF和MMP-2。但至今尚未发现与IH病程密切相关、特异度敏感度较强的血清标志物,本文就此方面的研究进展进行综述。

关键词: 婴幼儿血管瘤, 标志物, 发病机制

Abstract: Infantile hemangioma (IH) is the most common benign tumor in childhood, which has unique natural history with early proliferation and spontaneous involution courses. However its pathogenesis has not been elucidated, especially its specific biomarkers. In this paper, the research progress of this aspect was reviewed. Histologic biomarkers were consist of angiogenesis, placenta, apoptosis, hypoxia, inflammation, lymphatic, stem cell, pericyte and mast cell associated markers. Humoral biomarkers contained serum and urine markers, the former mainly had the cytokines such as estrogen and VEGF, the latter included bFGF and MMP-2. But so far there were not serum markers found to be closely related to the course of IH with strong sensitivity and specificity.

Key words: Infantile hemangioma, Marker, Pathogenesis

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