组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2016, Vol. 12 ›› Issue (6): 375-377.doi: 10.3969/j.issn.1673-0364.2016.06.013

• 综述 • 上一篇    下一篇

miRNA在间充质干细胞成骨分化过程中的作用

陈军宝，肖苒，曹谊林   

  1. 中国医学科学院整形外科医院整形五科；中国医学科学院整形外科医院研究中心
  • 发布日期:2020-07-23

Role of MicroRNA in the Process of Osteogenic Differentiation of Mesenchymal Stem Cells

CHEN Junbao,XIAO Ran,CAO Yilin   

  1. The Fifth Department, Plastic Surgery Hospital of Chinese Academy of Medical Sciences,Peking Union Medical College;Research Center, Plastic Surgery Hospital of Chinese Academy of Medical Sciences,Peking Union Medical College;
  • Published:2020-07-23

摘要： 间充质干细胞作为种子细胞在组织工程和再生医学领域有极大的应用前景,尤其是在骨组织工程中的应用受到了广泛关注。间充质干细胞的成骨分化机制复杂,受到多方面因素的影响,不同种类的mi RNA可分别参与抑制或促进间充质干细胞的成骨分化,在其分化过程中具有核心作用。本文对不同作用的mi RNA进行归类和总结,期待为未来的研究提供思路。

关键词: 间充质干细胞, 微小核糖核酸, 成骨分化, 信号通路

Abstract: Mesenchymal stem cells have great application prospects in tissue engineering and regenerative medicine as seed cells, especially have evoked the extensive attention in the application of bone tissue engineering. Mechanisms of osteogenic differentiation of mesenchymal stem cells are complicated. It is affected by various factors. Different kinds of miRNA can inhibit or promote the osteogenic differentiation of mesenchymal stem cells respectively, it plays a key role in the differentiation process. In this paper, miRNA in different roles was classified and summarized, expecting to provide ideas for future research.

Key words: Mesenchymal stein cells, MicroRNA, Osteogenic differentiation, Signal pathway

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