组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2019, Vol. 15 ›› Issue (3): 159-184.doi: 10.3969/j.issn.1673-0364.2019.03.008

• 论著 • 上一篇    下一篇

自体浓缩生长因子治疗男性雄激素源性脱发的临床应用20例

Tan   

  1. 上海交通大学医学院附属第九人民医院整复外科
  • 收稿日期:2019-01-19 修回日期:2019-03-21 出版日期:2019-06-20 发布日期:2019-06-20
  • 作者简介:谢芸,E-mail:amiyayun@qq.com;李青峰,E-mail:dr.liqingfeng@yahoo.com

Application of Autologous Concentrated Growth Factor (CGF) in Treating Androgenetic Alopecia (AGA): 20 Cases

TAN Pohching,ZHOU Shuangbai,WU Wei,LIU Kai,XIE Yun,LI Qingfeng   

  • Received:2019-01-19 Revised:2019-03-21 Online:2019-06-20 Published:2019-06-20

摘要： 目的 探索自体浓缩生长因子(Concentrated growth factor,CGF)治疗雄激素源性脱发(Androgenetic alopecia,AGA)的效果。方法 20例AGA患者采用自体CGF进行脱发区头皮皮下注射治疗,治疗后随访至少12周,分别于治疗前和治疗后第4周、第8周、第12周进行疗效评估。通过治疗前后照片、总体美观改善(GAIS)量表、皮肤镜图像、患者满意度调查问卷综合评价治疗的有效性。另外,观察注射区域是否有感染、红肿、破溃等不良反应,以评价治疗的安全性。结果 大体照片可见注射CGF后头发覆盖率显著增加,脱发外观改善;GAIS量表评分提示CGF治疗AGA有效。皮肤镜检查显示整体毛发密度及终毛/毳毛比例(T/V率)增加。患者满意度达85%。20例患者均未在随访期间出现治疗相关不良反应。结论 CGF治疗AGA安全、有效,操作简单、技术易掌握,可作为AGA的新型治疗方法。

关键词: 浓缩生长因子, 雄激素源性脱发, 自体生长因子, 毛发再生治疗

Abstract: Objective To explore the clinical effect of Concentrated Growth Factor(CGF)in treating Androgenetic Alopecia(AGA).Methods Twenty cases of AGA patients were treated with subcutaneous injection of CGF in alopecia area and were followed up for at least 12 weeks after treatment.The effectiveness were evaluated before and after treatment for 4,8,12 weeks.The efficacy of the treatment was comprehensively evaluated by digital photographs,Global Aesthetic Improvement Scale(GAIS)scale,trichoscopy images and the patient satisfaction questionnaire.The safety of the treatment was evaluated by observing the signs of infection,swelling or ulceration in the injection area.Results Gross photographs showed that the hair coverage increased significantly and the appearance of hair loss improved after the injection of CGF.The GAIS score suggested that CGF was effective for the management of AGA.The hair density and the ratio of terminal hair/vellus hair(T/V ratio)were increased showed by trichoscopy images.The patients'satisfaction rate was 85%.No side effects was observed during the follow-up period.Conclusion CGF is a safe and effective method for the treatment of androgenic alopecia.It is easier to produce and master and may be used as a novel therapy for the management of AGA.

Key words: Concentrated growth factor, Androgenetic alopecia

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