自体脂肪移植后细胞存活与再生中自噬机制的研究进展

组织工程与重建外科杂志 ›› 2023, Vol. 19 ›› Issue (4): 420-.

自体脂肪移植后细胞存活与再生中自噬机制的研究进展

出版日期:2023-08-01 发布日期:2023-09-06

Advances on autophagy mechanism in cell survival and regeneration after autologous fat grafting

Online:2023-08-01 Published:2023-09-06

摘要/Abstract

摘要：

　自体脂肪移植现已广泛应用于整形外科，但术后体积保留率不稳定仍是临床面临的主要问题，其原因在于对移植后细胞存活与再生的机制理解不充分。细胞自噬现象在代谢适应、细胞分化、抑制凋亡等方面起重要作用，在自体脂肪移植中也有诸多研究进展。本文就相关研究进行综述，重点讨论自体脂肪移植后脂肪细胞、脂肪干细胞的自噬，及自噬与炎症反应和血管重建的关系。自体脂肪移植后细胞自噬现象与其存活与再生密切相关，适度促进自噬可以提高移植后细胞存活与再生。

关键词:

自噬 , 　自体脂肪移植 , 　体积保留率 , 　存活 , 　再生

Abstract:

Autologous fat grafting has been widely used in plastic surgery. However, the unstable volume retention rate has

always been a significant problem, which is fundamentally due to the inadequate understanding of the mechanism of cell survival

and regeneration after transplantation. Autophagy plays a vital role in metabolic adaptation, cell differentiation and apoptosis inhibition, and many advances have been made in autophagy after autologous fat grafting. This review focused on the autophagy ofadipocytes and adipose-derived stem cells and the relationship between autophagy and inflammation and vascular remodeling. It

turned out that autophagy was closely related to cell survival and regeneration after autologous fat grafting, and moderately promoting autophagy may postoperatively improve the volume retention rate.

Key words:

Autophagy, 　Autologous fat grafting, 　Volume retention rate, 　Survival, 　Regeneration

贾昕宇, 李发成. 自体脂肪移植后细胞存活与再生中自噬机制的研究进展[J]. 组织工程与重建外科杂志, 2023, 19(4): 420-.

JIA Xinyu, LI Facheng. Advances on autophagy mechanism in cell survival and regeneration after autologous fat grafting[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2023, 19(4): 420-.