组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2019, Vol. 15 ›› Issue (1): 25-28.doi: 10.3969/j.issn.1673-0364.2019.01.007

• 论著 • 上一篇    下一篇

负压引流联合自体富血小板凝胶治疗糖尿病足的临床疗效

谢娟，方颖，曹东升，吕阳   

  1. 安徽医科大学第二附属医院整形外科
  • 收稿日期:2018-11-09 修回日期:2018-12-20 出版日期:2019-02-20 发布日期:2019-02-20
  • 作者简介:曹东升(E-mail:cdsh912@sohu.com)。

Vacuum Sealing Drainage Combined with Autologous Platelet-rich Gel for the Treatment of Diabetic Foot

XIE Juan,FANG Ying,CAO Dongsheng,LU Yang   

  1. Department of Plastic Surgery,The Second Hospital of Anhui Medical University,Anhui 230601,China)
  • Received:2018-11-09 Revised:2018-12-20 Online:2019-02-20 Published:2019-02-20
  • Contact: 安徽省全科医学临床科研课题(2016QK062)

摘要： 目的 观察负压引流联合自体富血小板凝胶治疗糖尿病足的临床疗效。方法 自2016年7月至2018年2月,将60例糖尿病足溃疡(Diabetic foot ulcer,DFU)患者随机分为实验组和对照组,每组30例。实验组采用自体富血小板凝胶(Autologous platelet-rich gel,APG)联合封闭负压引流(Vacuum sealing drainage,VSD)治疗,对照组仅采用VSD治疗。比较两组患者的治愈率、愈合时间、创面细菌转阴时间及组织学表现。结果 实验组各时间点治愈率均高于对照组(P<0.05);实验组创面愈合时间、细菌转阴时间均少于对照组(P<0.05)。结论 VSD联合APG治疗DFU具有促进创面愈合及缩短愈合时间的作用。

关键词: 自体富血小板凝胶, 封闭负压引流, 糖尿病足

Abstract: Objective To observe the clinical effects of vacuum sealing drainage(VSD)combined with autologous platelet-rich gel(APG)for the treatment of diabetic foot.Methods From July 2016 to February 2018,60 patients with diabetic foot ulcer(DFU)were randomly divided into two groups:experimental group(n=30)and control group(n=30).The experimental group was treated by VSD combined with APG,while the control group was treated by VSD only.The cure rate,healing time,time of bacterial turnover and histological appearance of the two groups were compared.Results The cure rate of the experimental group was higher than that of the control group at all time points(P<0.05).The time of wound healing and bacterial turnover in experimental group were both lower than that in control group(P<0.05).Conclusion VSD combined with APG for the treatment of DFU is effective in promoting the wound healing and shortening the healing time.

Key words: Autologous platelet-rich gel, Vacuum sealing drainage, Diabetic foot

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