组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2018, Vol. 14 ›› Issue (2): 92-112.doi: 10.3969/j.issn.1673-0364.a479

• 综述 • 上一篇    下一篇

稀土上转换材料活体干细胞示踪技术的研究进展

张慧中，刘凯   

  1. 上海交通大学医学院附属第九人民医院整复外科
  • 收稿日期:2018-01-06 修回日期:2018-01-30 发布日期:2020-07-23

Research Progress of Lanthanide-based Up-conversion Nanoparticles in Multimodal Stem Cell Labelling In Vivo

ZHANG Huizhong,LIU Kai   

  1. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine
  • Received:2018-01-06 Revised:2018-01-30 Published:2020-07-23

摘要： 干细胞治疗是组织修复重建的重要方法,但细胞活动与疗效间的关系缺乏实时精确且无创的验证手段。分子影像学可以为无创示踪提供重要的研究手段,其中稀土来源的上转换纳米材料(UCNP)具备强于常用造影剂的MRI、CT造影功能。本文就UCNP的发展历史、制备、示踪干细胞的研究现状和肿瘤相关研究的启示进行综述。

关键词: 分子影像学, 稀土上转换纳米材料, 干细胞活体示踪, 多模态生物影像学

Abstract: Stem cell therapy holds great promise in tissue regeneration and reconstruction. However, the underlying mechanisms remain elusive due to the lack of effective and noninvasive approaches during therapeutic processes. Within different strategies of molecular imaging, lanthanide-based up-conversion nanoparticles (UCNP) have been explored as imaging agents for luminescence imaging, magnetic resonance imaging (MRI) and computerized tomography (CT). As luminophore, UCNPs are preferable to other bioimaging probes. In this paper, the development history, preparation, the research status of stem cell tracer and the implications of tumor related research of UCNP were reviewed.

Key words: Molecular imaging, Lanthanide-based up-conversion nanoparticles, Stem cell tracking in vivo, Multimodal bioimaging

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