Abstract: Objective To explore the effects and application prospect of the medical collagen-hydroxyapatite artificial bone (CHA) for sellar reconstruction. Methods From December 2013 to December 2014, 80 patients with pituitary adenoma were treated by endoscopic endonasal transsphenoidal surgery. All the patients were divided into two groups randomly. The patients of experimental group were used with CHA for sellar reconstruction, while the control group were treated by the traditional method. All the patients were followed up for 3-6 months. The general conditions, complications and sellar reconstruction of the 2 groups were observed and compared. Results There were no significant differences of operation time, blood loss and total resection rate between the 2 groups (P>0.05). Significant difference of the nasal cerebrospinal leaks was observed in the 2 groups (P0.05). New bone formation was observed in experimental group according to the CT results, and the CT value increased to the normal. Compared with the control group, the difference was significant (P<0.05). Conclusion The endoscopic transsphenoidal surgery for pituitary tumors is widely applied with minimal invasiveness. But the cerebrospinal fluid leakage is still a common complication. Using CHA for sellar reconstruction can reduce the nasal cerebrospinal fluid leaks.

Key words: Collagen-hydroxyapatite, Endoscope, Pituitary neoplasms, Cerebrospinal leak, Sellar reconstruction