Abstract: Objective To compare the efficacy and safety of simply topical timolol 0.5%cream and timolol combined with intralesional Diprospan in the treatment of thick superficial infantile hemangiomas(IH).M ethods From January to November 2015,43 patients with thick superficial IH(2～6 mm)were recruited for a self-control study.Half lesion was treated with topical timolol 0.5%cream simply,while the other was treated with topical timolol 0.5%cream combined with Diprospan injection.Cream was applied four times daily for fivemonths,and the injection of Diprospan was given every 4 weeks.The injection time depended on tumor thickness and the effect,when the depth of lesion was less than 2 mm or no further improvementwas observed after three treatment procedures,injection treatment should be stopped.Finally,according to the thickness,the color and area score,the effective rate and the incidence rate of adverse reaction were compared between the two groups.Results Thirty-eight patients with thirty-night lesions finished the research.The efficacy rates of topical timolol group and combined treatment group were 92.3%and 97.4%,no significant difference was observed.The combined treatmentgroup exhibited better effect than timolol cream group,especially in the involution of thickness,color and onset time,while not in the involution of area.The side effects included ulceration(5.13%)and soft tissue atrophy(5.13%) were observed in combined treatment group and peeling(2.56%)in both group.Conclusion Compared with simply topical cream,intralesional Diprospan combined with topical timolol 0.5%cream has a better effect for treating superficial IH with a certain protruding degree in the aspects of thickness,color and onset time.

Key words: Timolol, Diprospan, Hormone injection, Superficial infantile hemangiomas