Abstract: Pulsed dye laser (pulsed dye laser, PDL) is still the gold standard to the treatment of port-wine stain (PWS), however, few PWS are lightened completely with PDL. PDL-resistant PWS exist in cutaneous laser practice and constitute a difficult management problem. Nowadays, factors that have resulted in the high degree of therapeutic recalcitrance are identified, and some experimental strategies are addressed, such as: photodynamic therapy, the laser application with deeply penetration, angiogenesis inhibitors, etc. The 755 nm alexandrite laser, compared to 595 nm pulsed dye laser, have deeper penetrating of organization, less melanin absorption, higher laser energy. In this paper, the 755 nm alexandrite laser for the treatment of port-wine stains was reviewed.

Key words: Alexandrite laser, Port-wine stain, Efficacy