Abstract: The reconstruction of tissue and organ by tissue engineering is one of the potential treatments for the tissue defect and organ failure. The current main problem of tissue engineering is how to build the blood supply timely after engineered tissue implantation to avoid shrinkage or failed tissue function. The recent literature about the vascularization of engineered tissues was extensively reviewed and divided up into four parts: the modification of scaffold, addition of cells, addition of angiogenic factors or gene therapy, in vitro or in vivo prevascularization, according to the difference of vascularization strategies. The advantages and limitations of various kinds of vascularization strategies were analyzed. Furthermore,the future development direction was put forward.

Key words: Tissue engineering, Vascularization, Scaffold, Angiogenic factor, Axial vessel