Abstract: Objective　To investigate the clinical application effect of the pedicled lateral thoracic artery perforator flap in breast reconstruction after breast conserving surgery and its tumor safety. Methods　A total of 41 breast cancer patients who underwent breast-conserving surgery using pedicled lateral thoracic artery perforator flap from October 2020 to May 2022 were included in the study. Age ranged from 35 to 82 years old, 56.4 years on average. All the paitents were females. The tumors were all unilateral, with 15 cases on the left and 26 cases on the right side. The locations of the masses were the out upper lateral quadrant (n=21), the outer lower quadrant (n=6), the inner upper quadrant (n=9), the inner lower quadrant (n=3), and the posterior nipple (n=2). The diameter ranged from 0.9 cm to 4.0 cm. There were luminal A type (n=14), luminal B type (n=17), HER2 overexpression type (n=7), and triple negative type (n=3); There were 19 cases in stage Ⅰ, 16 cases in stage Ⅱ, and 6 cases in stage Ⅲ. Survival of the flap, the shape of the reconstructed breast and the local recurrence were observed after operation. Results　The average mass of tumor and breast tissue resected was about 40 g. All flaps survived. There was no reduction in flap volume after radiotherapy. All 41 patients were followed up for 3 to 24 months (12 months on average) with satisfactory results. No recurrence of breast cancer happened. Conclusion　The pedicled lateral thoracic artery perforator flap is a relatively simple and reproducible reconstructive technique, which greatly improves the breast shape after breast conserving, and is worthy of clinical application and promotion.

Key words: Breast cancer, 　Breast conserving surgery, 　Lateral thoracic artery perforator flap