Abstract: 　Studies have found that there are stem cells with osteogenic differentiation ability in the buccal fat pad, which can be used as seed cells for bone tissue engineering to induce new bone formation. The buccal fat pad contains two components, mature adipose tissue and stromal vascular fraction, from which can separately obtaine dedifferentiated fat cell and adipose stem cells, both of them have osteogenic differentiation ability. In this paper, the buccal fat pad-derived stem cells, from the discovery of osteogenic ability, comparison with other stem cells, factors influencing osteogenesis, the role of scaffolding, to the clinical trials, were all reviewed, and the research and application progress of buccal fat pad-derived stem cells was summarized to provide a reference of the source of seed cells in bone tissue engineering.

Key words: Buccal fat pad, 　Stem cell, 　Bone regeneration, 　Tissue engineering