Journal of Tissue Engineering and Reconstructive Surgery ›› 2023, Vol. 19 ›› Issue (2): 193-.

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Progress in prevention and treatment of skin flap necrosis induced by ischemic reperfusion

  

  • Online:2023-04-01 Published:2023-05-10

Abstract:

 Flap ischemia-reperfusion injury often occurs after skin flap transplantation surgery, which is an important cause
of partial or total necrosis of skin flap. Nowadays, the pathogenesis of flap ischemia-reperfusion injury is not completely clear.
It is generally believed that FIRI is related to the outbreak of reactive oxygen species, the infiltration of neutrophils and the ob
struction of revascularization. Nanozyme is a kind of nano-material with enzyme-like properties, which has the advantages of low
cost, good stability, simple preparation and easy storage. It can directly regulate the redox balance in cells and overcome many
limitations of natural enzyme in enzyme therapy. As an ideal antioxidant, nanozyme will play a vital role in the field of biomed
icine. In this paper, the mechanism of flap ischemia-reperfusion injury and the research and clinical application of treatment
methods in recent years were reviewed, and the application of nanozyme in ischemia-reperfusion injury diseases was introduced,
aiming to provide theoretical basis and new thinking about the treatment of flap ischemia-reperfusion injury.

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