Journal of Tissue Engineering and Reconstructive Surgery ›› 2023, Vol. 19 ›› Issue (3): 275-.

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Application of stromal cell-derived factor-1 α combined with platelet-rich fibrin in bone regeneration of dental implants

  

  • Online:2023-06-01 Published:2023-07-05

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Abstract:

Objective　To investigate the effect of stromal cell derived factor-1 α combined with platelet-rich fibrin on alve
olar bone regeneration after dental implantation. Methods　A total of 120 dental implant patients were selected from June 2019
to December 2020. According to random number table method, patients were divided into experimental group (n=60) and con
trol group (n=60). The control group was treated with platelet-rich fibrin + artificial bone meal, and the experimental group was
treated with stromal cell-derived factor-1 α + platelet-rich fibrin + artificial bone meal. Bone mineral density, bone thickness,
alveolar bone lip and tongue width, gingival health, implant success rate, complete healing rate, local infection rate, implant sta
bility coefficient (ISQ), probing depth (PD) and gingival crevicular bleeding index (SBI) were compared between the two groups.
Enzyme-linked immunosorbent assay and Western blot was used to detect the expression levels of platelet-derived growth factor
(PDGF), transforming growth factor (TGF-β) and bone morphogenetic protein 2 (BMP-2) in gingival crevicular fluid and bone
chips 7 days after operation. Results　The expression levels of PDGF, TGF-β and BMP-2 protein in the experimental group
were higher than those in the control group on the 7th day after surgery (P<0.05). The bone density, bone thickness, alveolar bone
lip-lingual width and implant stability coefficient in the experimental group were higher than those in the control group at the 6th
month after operation (P<0.05). The probing depth and gingival crevicular bleeding index were lower than those in the control 
group (P<0.05). There was no significant difference in the implant success rate, complete healing rate and local infection rate be
tween the two groups 6 months after surgery (P>0.05). Conclusion　Stromal cell derived factor-1 α combined with platelet-rich
fibrin can promote alveolar bone regeneration and repair in patients with dental implants, and the relevant mechanism may be
related to the up-regulation of PDGF, TGF-β and BMP-2 expression.

Key words:

mineral density