Abstract:

Congenital melanocytic nevus is a common skin developmental abnormality that can occur in any part of the

body where melanocytes are present. Its occurrence is closely related to somatic cell mutations， regulated by multiple

signaling pathways， and has diverse clinical manifestations. Surgical excision and dilator are still the main treatments for

CMN， and laser therapy is a powerful mean to eliminate pigmentation and remove satellite lesions. Targeted therapy and

immunotherapy are becoming a new direction for the treatment of congenital melanin giant nevi.

Key words:

Congenital melanocytic nevus, Pathogenesis, Somatic mutation, Targeted therapy