therapeutic principles and efficacy of this method in treating Alzheimer’s disease （AD）. Methods Patients underwent the

lymphatic/lymph node-venous shunt surgery in the cervical Ⅱ/Ⅲ region. Cognitive assessments， including the MMSE，MoCA， and NPI， were conducted before and one month after surgery to evaluate symptom improvement. PET-CT was used to

quantitatively analyze changes in intracranial Aβ protein levels. Color Doppler ultrasound was employed to measure the patency of the internal jugular vein and detect wall-adherent thrombus formation. Postoperative follow-up within one month included monitoring wound healing， hematoma or fluid accumulation， lymphatic leakage， postoperative delirium，headaches， and other discomforts. Results This study included 7 AD patients （3 males and 4 females） with an average age of 65（57-71） years. All patients had AD with dementia. Compared to preoperative scores， one month postoperatively， MMSE improved by 0（-2，1） points （P=0.581）， MoCA improved by 0（-1，1） points （P=1.000）， NPI （frequency× severity） improved by 9（9，20） points （P=0.043）， and NPI caregiver distress improved by 2（2，6） points （P=0.026）. Color Doppler ultrasound indicated patent internal jugular venous flow without wall-adherent thrombus. No adverse reactions were observed. Three patients underwent PET-CT one month postoperatively， showing an average reduction of 12.3% in whole-brain Aβ protein levels. Conclusion The proposed lymphatic/lymph node-venous shunt surgery in the cervical Ⅱ/Ⅲ region can divert the extracranial segment of intracranial lymphatic drainage， promote the clearance of pathological proteins， reduce intracranial Aβ protein levels， and improve clinical symptoms. This procedure may become a viable treatment option for AD， advancing the development of surgical interventions for AD.