Research Biocompatibility of the Poly(l-lactic acid) Nano-fibrous Scaffolds with Spinal Cord Tissues in Rats

doi:10.3969/j.issn.1673-0364.2009.06.007

Journal of Tissue Engineering and Reconstructive Surgery ›› 2009, Vol. 5 ›› Issue (3): 143-147.doi: 10.3969/j.issn.1673-0364.2009.06.007

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Research Biocompatibility of the Poly(l-lactic acid) Nano-fibrous Scaffolds with Spinal Cord Tissues in Rats

ZHANG Yanqing¹,ZENG Yuanshan¹,HE Liumin²,QUAN Daping²,LI Yan¹

1 Division of Neuroscience; Department of Histology and Embryology;Zhongshan School of Medicine;Sun Yat-sen University;Guangzhou 510080;China;2 Institute of Polymer Science;School of Chemistry and Chemical Engineering;Guangzhou 510275;China.;

Published:2020-07-23
Contact: 国家自然科学基金(30771143);;广东省自然科学基金(07117373)

Abstract

Abstract: Objective To explore the biocompatibility of the Poly(l-lactic acid)(PLLA) nano-fibrous scaffold with spinal cord tissue of rats.Methods PLLA three-dimensional(3D) scaffolds with macro/micro-pores and nano-fibrous structure were fabricated by phase separation from a ternary PLLA/dioxane/water system.MSCs-PLLA nano-fibrous scaffolds complex were constructed in vitro.Twelve SD rats were divided into two groups:control injured group and MSCs transplanted group.T10 spinal cord segment was exposed,and then trans...

Key words: PLLA, Nano-fibrous scaffold, Bone marrow mesenchymal stem cells, Spinal cord injury, Biocompatibility

CLC Number:

ZHANG Yanqing,ZENG Yuanshan,HE Liumin,QUAN Daping,LI Yan. Research Biocompatibility of the Poly(l-lactic acid) Nano-fibrous Scaffolds with Spinal Cord Tissues in Rats[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2009, 5(3): 143-147.

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Research Biocompatibility of the Poly(l-lactic acid) Nano-fibrous Scaffolds with Spinal Cord Tissues in Rats

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