Abstract: Temporomandibular joint disc perforation is one of the severe structural disorder in temporomandibular disorders (TMD). The main clinical manifestations are pain, sound and mandibular dyskinesias. At present, the prognosis of clinical treatment is poor, and it is difficult to restore the normal anatomical morphology and function of the articular disc. The development of tissue engineering technology has made it possible to regenerate the articular disc. It has been found that by seeding mesenchymal stem cells on a strong biodegradable scaffold, fibrocartilage differentiation is achieved under the stimulation of growth factors, and collagen fibers and glycosaminoglycans are secreted. Eventually, the scaffold is replaced by healthy tissue and the joint disc is regenerated. In this paper, the research progress of tissue engineering technology in articular disc regeneration was reviewed.

Key words: Temporomandibular disorders, 　Articular disc perforation, 　Tissue regeneration, 　Tissue engineering