Abstract: Blood supply is the most important thing regarding skin's maintenance and transplantation, although tissue engineering skin have been commercialized and used in clinic, it has failed to achieve the vascularization. The neovascularization of tissue engineering skin at present is mainly rely on seed cells that can promote vascularization and a variety of growth factors. As the development of induced pluripotent stem cells, electrostatic spinning, and the biological printing technology, new scaffolds combined with the corresponding seed cells and cytokines can be designed to simulate the growing environment of body accurately to promote vascularization of tissue engineering skin. In this paper, the research progress of neovascularization in tissue engineering skin was reviewed.

Key words: Skin tissue engineering, Neovascularization, Stem cells, Cytokines, Scaffolds