Abstract:

Fibrous dysplasia （FD） is a benign disease caused by the replacement of normal bone tissue by abnormal

fibrous-bone connective tissue， often occurring in the craniofacial area， with malignancy being one of the most devastating

progressions. Its poorly understood risk factors and pathogenesis， potentially fulminant clinical manifestations， and advanced

spread make craniofacial fibrous dysplasia malignant a challenge. In this paper， the pathogenesis， clinical manifestations，

treatments， and prognosis of craniofacial fibrous dysplasia malignant were reviewed to provide a reference for its clinical

diagnosis， treatment， and further research.

Key words:

Fibrous dysplasia, Craniofacial, Malignancy, Malignant tumor, Surgical treatment