Journal of Tissue Engineering and Reconstructive Surgery ›› 2024, Vol. 20 ›› Issue (3): 293-.

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Fluid mechanics finite element analysis of 3D printed porous biological scaffolds with different microstructures based on cell adhesion

  

  • Online:2024-06-01 Published:2024-07-05

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Abstract:

Objective To study the influence of 3D-printed bone scaffolds with different pore morphologies on cell
adhesion. Methods Utilizing MSLattice software， four porous structures with different pore morphologies， namely cubic，
Hexagon， diamond， and gyroid， were designed. The principles of finite element analysis （FEM） and computational fluid
dynamics （CFD） were employed using Siemens Star CCM+ software to simulate the fluid flow within the four scaffold
structures， model the process of cell adhesion， measure the fluid flow velocity and pressure within the scaffold， as well as the
fluid permeability and the thickness of the adhesion layer. Results Upon the passage of fluid through the four types of
scaffolds， the pressure gradually diminished. However， due to the relatively regular structure of the scaffolds， the pressure
exhibited a gradient distribution. The simulated pressure values before fluid flow through the four types of scaffolds were， in
sequence： Gyroid>Cubic>Diamond>Hexagon. Flow velocity： Cubic>Gyroid>Diamond>Hexagon. The permeability of the four
types of scaffolds： Diamond>Hexagon>Cubic>Gyroid. Adhesion layer thickness： Gyroid>Hexagon>Cubic>Diamond.
Conclusion The fluid mechanics analysis results show that the gyroid scaffold has lower permeability and the highest
adhesion layer thickness， which is more conducive to cell adhesion.

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