Objective To explore the clinical application and postoperative effects of Body-jet hydrodynamic liposuction system in breast augmentation with autologous fat transplantation. Methods From September 2012 to December 2013, 18 cases received breast augmentation with autologous fat transplantation using Body-jet hydrodynamic liposuction system. The autologous fat was collected and purified by Body-jet hydrodynamic liposuction system, then was injected to each layer of breast tissue multi-levelly and multi-dimensionally. The fat dosage of unilateral breast injection ranged from 100-250 mL. Results After 6 to 12 months' follow-up, all 18 cases achieved good results including full-round contour, natural breast shape and soft feeling of palpation. Satisfactory outcome were received without severe complications. Conclusion Body-jet hydrodynamic liposuction technique is safe, effective, easy to operate, and is an ideal method for breast augmentation with autologous fat transplantation.