Aiming at the engineering problem of flow loss, an optimization design method of tubing hanger outlet is proposed on the basis of drag coefficient method, which considers the structural characteristics of tubing hanger, as well as the position and function of tubing hanger. By using the FLUENT software, a finite element model for tubing hanger is developed and the fluid flow in the tubing hanger is simulated. The results obtained by the drag coefficient method and the numerical results show that the best tubing hanger outlet angle is between 11° and 12°.