Abstract: The analysis on interference between upstream and downstream risers is an important design part of riser design in deep water. After introducing different wake theories used for top tensioned riser (TTR), we build the TTR model for interference analysis with FLEXCOM software. The results obtained with different wake models are compared, showing that the clearance under Blevins model is smaller than that under Huse model. In practical engineering projects, it is recommended to choose the wake model based on environment condition for analysis and determine the riser space based on the interference analysis results and the need of well slot arrangement, etc