关键词: 心脏原发性肿瘤, 非黏液瘤性肿瘤, 组织病理, 诊断

Abstract: Objective: To investigate the clinicopathologic and diagnostic features of non-myxomatous cardiac tumors for improving the diagnostic level of the disease. Methods: Nineteen patients with pathologically confirmed primary non-myxomatous cardiac tumor during January 2009 to July 2016 at Ruijin Hospital were enrolled in this study. The clinical and pathologic features, imaging findings and immunophenotype of these cases were analyzed retrospectively and relevant literatures were reviewed. Results: Nine of the 19 cases were benign tumor (9/19), including 3 hemangioma, 3 lipoma, 2 papillary fibroelastoma and 1 schwannoma. Eight cases were malignant tumors (8/19), including 5 angiosarcoma, 1 malignant mesothelioma, 1 synovial sarcoma and 1 diffuse large B cell lymphoma.Two cases were intermediate tumors (2/19), including 1 fibromatosis and 1 composite hemangioendothelioma. Clinically, most of the patients presented with recurrent chest tightness and dyspnea. In patients with benign tumor, symptoms was mild or even absent and some patients were discovered during routine physical examination. Serious symptoms were seen in patients with malignant tumor. Conclusions: Primary cardiac non-myxomatous tumors are extremely rare,consisting various types of tumors and lacking specific clinical manifestations. The diagnosis of benign tumor is relatively easier. The malignant tumors are mainly sarcoma,especially angiosarcoma. Other types of malignant tumors are rare and their histomorphology are of diversive state; the definite diagnosis depends on histopathology and immunohistochemical examination and molecular detection.

Key words: Primary cardiac tumors, Non-myxomatous cardiac tumors, Histopathology, Diagnosis