剑桥-霍普金斯不宁腿量表诊断中国人群不宁腿综合征的临床研究

doi:10.16150/j.1671-2870.2018.02.009

诊断学理论与实践 ›› 2018, Vol. 17 ›› Issue (02): 165-169.doi: 10.16150/j.1671-2870.2018.02.009

剑桥-霍普金斯不宁腿量表诊断中国人群不宁腿综合征的临床研究

张晶¹, 陈捷², 马建芳², 徐宜¹, 洪坚锋¹

1.上海黄浦区五里桥街道社区卫生服务中心全科,上海 200023;
2.上海交通大学医学院附属瑞金医院神经内科,上海 200025

收稿日期:2018-01-16 出版日期:2018-04-25 发布日期:2018-04-25
通讯作者: 洪坚锋 E-mail: 115693267@qq.com
基金资助:
国家重点研发计划项目(2016YFC1306000)

Validation of Cambridge-Hopkins questionnaire for diagnosing restless legs syndrome in a Chinese cohort

ZHANG Jing¹, CHEN Jie², MA Jianfang², XU Yi¹, HONG Jianfeng¹

1. Wuliqiao Community Health Service Center, Huangpu District, Shanghai 200023, China;
2. Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2018-01-16 Online:2018-04-25 Published:2018-04-25

摘要/Abstract

摘要： 目的：在中国人群中对自填型剑桥-霍普金斯不宁腿量表（Cambridge-Hopkins questionnaire for restless legs syndrome, CH-RLSq）诊断不宁腿综合征（restless legs syndrome/Willis-Ekbom disease, RLS/WED）的灵敏度和特异度进行验证。方法：共26例RLS/WED患者和21例对照（18例其他疾病患者和3名正常人）入组,其中其他疾病指类似RLS/WED表现的疾病（包括4例神经根病变,3例糖尿病周围神经病变,4例痛性痉挛,1例静脉曲张,另6例患者的诊断暂不确定）,所有对象均进行CH-RLSq量表检测,进行临床诊断与问卷诊断的一致性研究,并同时记录RLS/WED患者的临床资料。结果：RLS/WED的临床诊断和CH-RLSq量表的诊断具有较好的一致性（Kappa=0.745, McNemar test: P=0.216）。CH-RLSq量表诊断RLS/WED的灵敏度为80.8%,特异度为95.2%。RLS/WED患者中女性患者较多见,且患者的家族史阳性率较高、合并症较多。结论：CH-RLSq量表在我国人群的RLS/WED诊断中具有较高的灵敏度和特异度,可用来作为筛查RLS/WED的问卷。

关键词: 不宁腿综合征, 剑桥-霍普金斯不宁腿量表, 问卷

Abstract: Objectives: To validate the application of CH-RLSq (Cambridge-Hopkins questionnaire for restless legs syndrome) in the diagnosis of Chinese RLS (restless legs syndrome) patients. Methods: Twenty-six RLS and 21 controls were enrolled in this study. RLS patients, "mimics" and healthy people were recruited from Out-patient Clinics of Department of Neurology and completed the CH-RLSq. Clinical data of RLS were also collected. The agreement of clinical RLS diagnosis with CH-RLSq diagnosis was assessed by kappa and Mcnemar tests. Results: CH-RLSq-based diagnosis was consistent with clinical diagnosis (kappa=0.745, McNemar test: P=0.216). The clinical characteristics of these RLS patients included female preference, high family history, and various concomitant diseases. Conclusion:CH-RLSq is a good screening questionnaire for diagnosing RLS in Chinese patients.

Key words: Restless legs syndrome, Cambridge-Hopkins questionnaire for restless legs syndrome, CH-RLSq, Questionnaire

中图分类号:

R742

张晶, 陈捷, 马建芳, 徐宜, 洪坚锋. 剑桥-霍普金斯不宁腿量表诊断中国人群不宁腿综合征的临床研究[J]. 诊断学理论与实践, 2018, 17(02): 165-169.

ZHANG Jing, CHEN Jie, MA Jianfang, XU Yi, HONG Jianfeng. Validation of Cambridge-Hopkins questionnaire for diagnosing restless legs syndrome in a Chinese cohort[J]. Journal of Diagnostics Concepts & Practice, 2018, 17(02): 165-169.

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剑桥-霍普金斯不宁腿量表诊断中国人群不宁腿综合征的临床研究

Validation of Cambridge-Hopkins questionnaire for diagnosing restless legs syndrome in a Chinese cohort

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