诊断学理论与实践

诊断学理论与实践 ›› 2019, Vol. 18 ›› Issue (2): 189-192.doi: 10.16150/j.1671-2870.2019.02.013

• 论著 • 上一篇    下一篇

局部晚期乳腺癌患者腋窝淋巴结转移范围的影响因素分析

王志威1, 张晓晓2, 王杰1, 魏敏1, 邵玉国1, 籍敏1, 杨莉1, 何奇1()   

  1. 1. 上海交通大学医学院附属国际和平妇幼保健院乳腺科，上海 200030
    2. 上海交通大学医学院附属瑞金医院超声科，上海 200025
  • 收稿日期:2018-10-10 出版日期:2019-04-25 发布日期:2019-04-25
  • 通讯作者: 何奇 E-mail:doc_hq@126.com
  • 基金资助:
    国际和平妇幼保健院院级课题(GFY 5502);国际和平妇幼保健院优秀青年医师培育计划(GFY 9307)

Influencing factors of axillary lymph node metastasis in patients with locally advanced breast cancer

WANG Zhiwei1, ZHANG Xiaoxiao2, WANG Jie1, WEI Min1, SHAO Yuguo1, JI Min1, YANG Li1, HE Qi1()   

  1. 1. Department of Breast, International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
    2. Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2018-10-10 Online:2019-04-25 Published:2019-04-25
  • Contact: HE Qi E-mail:doc_hq@126.com

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摘要：

目的：研究局部晚期乳腺癌患者腋窝淋巴结转移程度的影响因素。方法：回顾性收集我院2008年4月到2018年4月腋窝淋巴结转移≥4枚的233例乳腺癌患者的临床病理资料，比较腋窝淋巴转移N2组（141例）和N3组（92例）患者间的年龄、分子分型[Luminal A分子分型、人表皮生长因子受体2（human epidermal growth factor receptor 2，HER-2）阳性，三阴性]、肿瘤大小、组织学分级、雌激素、孕激素受体表达、HER-2表达及Ki-67表达的差异。结果：N2组患者中肿瘤大小为T1、T2、T3、T4的百分比分别为46.1%、49.6%、2.8%、1.4%;N3患者中肿瘤大小为T1、T2、T3、T4的百分比分别为27.2%、58.7%、13.0%、1.1%，与N2组比较，N3组患者的肿瘤直径更大（P=0.002）。而N2组与N3组患者在年龄、分子分型、组织学分级及雌激素受体、孕激素受体、HER-2、Ki-67表达方面差异均无统计学意义（P>0.05）。结论：局部晚期乳腺癌淋巴结转移范围与肿瘤大小（T分期）显著相关，而与乳腺癌患者的年龄、分子分型、组织学分级及雌激素受体、孕激素受体、HER-2、Ki-67表达无关。

关键词: 局部晚期乳腺癌, 分子分型, 腋窝淋巴结转移, 临床病理特征

Abstract:

Objective: To investigate the influencing factors of axillary lymph node metastasis in patients with locally advanced breast cancer. Methods: The clinical pathological data of 233 locally advanced breast cancer patients with at least 4 axillary lymph nodes metastasis from April, 2008 to April, 2018 in our hospital were collected retrospectively. The age, molecular type (luminal A/luminal B, HER-2 positive/negative, triple negative), tumor diameter, histological grade and the expression of ER/PR, HER-2, Ki-67 were compared between patients with N2 and N3 axillary lymph node metastasis. Results: Of the 233 locally advanced breast cancer patients, 141 patients were in Group N2 while 92 patients were in Group N3. The proportions of T1, T2, T3 and T4 in N2 group were 46.1%, 49.6%, 2.8% and 1.4%, respectively, whereas that in N3 group were 27.2%, 58.7%, 13.0% and 1.1%, respectively. The diameter of tumor was larger in N3 group than in N2 group(P=0.002）. There was no statistical difference between Group N2 and N3 in terms of age, molecular type, histological grade, ER/PR expression, HER-2 expression and Ki-67 expression (P>0.05). Conclusions: In locally advanced breast cancer, the number of axillary lymph nodes metastasis is correlated significantly with the diameter of tumor (T stage). while no correlations with age, molecular type, histological grade, ER/PR expression, HER-2 expression and Ki-67 expression are found.

Key words: Locally advanced breast cancer, Molecular type, Axillary lymph nodes metastasis, Clinical pathological characteristics

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