Abstract: Objective: To investigate the changes in arterial pulse wave velocity(PWV), ankle brachial index (ABI) and carotid plaque in type 2 diabetes mellitu patients receiving 2-year intensive therapy,and analyze their clinical significance and monitoring role on the prevention of large blood vessel lesions in type 2 diabetes mellitus patients. Methods: Two hundred and six patients with type 2 diabetes from January 2012 to December 2014 at Yuyuan Community Health Service Center, Huangpu District were enrolled. Patients were randomly divided into 2 groups: patients in group A received intensive therapy for 2 years , while patients in group B were given conventional therapy. Differences in blood glucose, blood lipid, PWV, ABI and carotid artery ultrasound indices between the two groups were compared after 24 months follow up. Results: Differences in systolic blood pressure,diastolic blood pressure,urinary protein,postprandial 2 hours blood glucose (2hPG), glycosylated hemoglobin (HbA1c),low density lipoprotein cholesterol (LDL-C), PWV were statistically significant between the two groups（P<0.05）. PWV was significantly lower in blood pressure controlled patients than in uncontrolled patients (P<0.05). In patients with course of diabetes <5 years, PWV in those with HbA1c controlled was significantly lower than those with HbA1c not controlled （P<0.05）. Conclusions: PWV, ABI and carotid artery plaque can objectively reflect the changes in structure and function of blood vessels for patients with type 2 diabetes mellitus, which has a guiding significance for prevention and delay of diabetic complication such as atherosclerosis.

Key words: Type 2 diabetic patients, Intensive treatment, Pulse wave velocity, Ankle-brachial index, Carotid plaques