The correlation between different fat distribution indices and dyslipidemia in middle-aged population in Shanghai

doi:10.16150/j.1671-2870.2019.02.011

Abstract

Abstract:

Objective: To investigate the correlation between different fat distribution indices and dyslipidemia in community residents of Songnan District in Shanghai. Methods: A survey was conducted among 550 community residents in Songnan District, Shanghai. Questionnaires was used to collect information on health status, medical history, and lifestyle. Subjects received physical examinations for height, body weight, waist circumference, and blood pressure measurement. Venous blood sample was collected after an overnight fast and blood lipids and glucose were tested. CT and FATSCAN software were used to measure abdominal visceral fat area and subcutaneous fat area. Results: The proportion of dyslipidemia among 550 community residents in Songnan District was 65.1%. Measures of fat distribution indices such as body-mass index (BMI), waist-hip ratio, waist circumference, visceral fat area, subcutaneous fat area in individuals with dyslipidemia were significantly higher than individuals with normal blood lipids (P<0.05). Multivariable logistic regression analysis showed that after adjustment for sex, age, current smoking, current drinking, educational attainment, systolic pressure, HbA1c, blood glucose-lowering treatment and insulin resistance, one-SD increase in waist-hip ratio was associa-ted with 87% increase in risks of having high LDL-cholesterol; one-SD increase in waist circumference was associated with 60% increase in risks of having low HDL-cholesterol and 45% increase in risks of having dyslipidemia. Conclusions: Most indicators of fat distribution such as BMI, waist-hip ratio, waist circumference, visceral fat area, and subcutaneous fat area are correlated with dyslipidemia, however, the degree of correlation is different. Waist-hip ratio might be more important in the association with high LDL-cholesterol. Waist circumference might be more important in the association with low HDL-cholesterol and dyslipidemia.

Key words: Fat distribution indices, Dyslipidemia, Risk

CLC Number:

R587.1

WANG Shanshan, ZHOU Yingxia, HU Lijuan, NIU Jingya, WANG Tiange, LI Mian, ZHAO Zhiyun, XU Yu, LU Jieli, XU Min, BI Yufang, NI Hengru. The correlation between different fat distribution indices and dyslipidemia in middle-aged population in Shanghai[J]. Journal of Diagnostics Concepts & Practice, 2019, 18(2): 177-182.

Figures/Tables 3

References 13

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组别	血脂正常组	血脂异常组	P值^a)
例数	192(34.9%)	358(65.1%)	/
年龄(岁)	51.6±4.4	52.5±4.1	0.015
男性	87(45.3%)	147(41.1%)	0.287
冠心病家族史	45(23.4%)	63(17.6%)	0.102
高中以上学历	67(34.9%)	121(34.8%)	0.703
目前吸烟	61(31.8%)	98(27.4%)	0.534
目前饮酒	50(26.3%)	85(24.1%)	0.887
收缩压(mmHg)	127.2±17.7	134.6±19.6	<0.001
舒张压(mmHg)	77.2±9.3	80.9±10.0	<0.001
TC (mmol/L)	4.51±0.50	5.50±0.95	<0.001
LDL-c (mmol/L)	2.05±0.45	2.57±0.73	<0.001
HDL-c (mmol/L)	1.40±0.28	1.33±0.31	0.004
TG (mmol/L)	1.09(0.82~1.43)	1.84(1.33~2.79)	<0.001
FPG (mmol/L)	5.0(4.7~5.5)	5.3(4.8~6.0)	0.001
PPG (mmol/L)	7.5(5.7~9.2)	8.2(6.5~11.1)	<0.001
HbA1c (%)	5.9(5.6~6.3)	6.1(5.8~6.6)	<0.001
HOMA-IR	1.3(0.8~2.0)	2.0(1.3~2.9)	<0.001
高血压	97(50.5%)	247(69.0%)	<0.001
糖尿病	29(15.1%)	101(28.2%)	<0.001
使用降糖药物	10(5.2%)	22(6.2%)	0.645
脂肪分布指标
BMI (kg/m²)	24.6±3.3	26.0±3.4	<0.001
腰臀比	0.88±0.06	0.90±0.05	<0.001
腰围(cm)	83.5±9.5	88.1±9.1	<0.001
皮下脂肪面积(cm²)	125.6 (89.6~179.2)	157.3 (114.0~204.3)	<0.001
内脏脂肪面积(cm²)	71.7 (48.9~110.7)	96.5 (69.9~125.2)	<0.001

模型	TC (mmol/L)	LDL-c (mmol/L)	HDL-c (mmol/L)	Log [TG(mmol/L)]
模型1
BMI (kg/m²)	0.031±0.011^a)	0.030±0.008^a)	-0.015±0.003^a)	0.017±0.003^a)
腰臀比	2.545±0.771^a)	2.420±0.570^a)	-1.303±0.234^a)	1.517±0.212^a)
腰围 (cm)	0.015±0.004^a)	0.013±0.003^a)	-0.007±0.001^a)	0.008±0.001^a)
Log [皮下脂肪面积(cm²)]	0.475±0.182^a)	0.415±0.135^a)	-0.289±0.055^a)	0.268±0.051^a)
Log (内脏脂肪面积(cm²))	0.510 ± 0.173^a)	0.584±0.128^a)	-0.373±0.052^a)	0.377±0.047^a)
模型2
BMI (kg/m²)	0.012±0.013	0.021±0.009^b)	-0.012±0.004^a)	0.006±0.003
腰臀比	1.507±0.841	1.960±0.623^a)	-1.217±0.259^a)	0.957±0.223^a)
腰围 (cm)	0.009±0.005	0.011±0.004^a)	-0.006±0.002^a)	0.004±0.001^a)
Log [皮下脂肪面积(cm²)]	0.296±0.183	0.313±0.137^b)	-0.248±0.057^a)	0.172±0.049^a)
Log (内脏脂肪面积(cm²))	0.208±0.196	0.472±0.145^a)	-0.374±0.059^a)	0.233±0.052^a)

模型	高TC血症	高LDL-c血症	低HDL-c血症	高TG血症	血脂异常
模型1
BMI (kg/m²)	1.31(1.10~1.57)^a)	1.29(0.96~1.73)	1.38(1.06~1.80)^b)	1.31(1.09~1.58)^a)	1.56(1.28~1.90)^a)
腰臀比	1.35(1.11~1.65)^a)	1.92(1.35~2.73)^a)	1.36(1.00~1.85)^b)	1.69(1.36~2.10)^a)	1.69(1.36~2.08)^a)
腰围 (cm)	1.43(1.19~1.73)^a)	1.51(1.11~2.07)^a)	1.50(1.13~1.98)^a)	1.60(1.30~1.95)^a)	1.83(1.48~2.26)^a)
Log [皮下脂肪面积([cm²)]	1.37(1.09~1.71)^a)	1.22(0.80~1.85)	1.51(1.04~2.19)^b)	1.56(1.21~2.03)^a)	1.62(1.29~2.03)^a)
Log [内脏脂肪面积(cm²)]	1.34(1.11~1.62)^a)	1.75(1.19~2.58)^a)	1.42(1.05~1.90)^b)	1.80(1.43~2.25)^a)	1.74(1.43~2.12)^a)
模型2
BMI (kg/m²)	1.13(0.92~1.39)	1.22(0.86~1.72)	1.49(1.09~2.05)^b)	0.91(0.72~1.14)	1.21(0.97~1.51)
腰臀比	1.23(0.99~1.53)	1.87(1.25~2.79)^a)	1.48(1.05~2.09)^b)	1.28(1.00~1.64)^b)	1.40(1.11~1.76)^a)
腰围 (cm)	1.27(1.02~1.57)^b)	1.51(1.04~2.20)^b)	1.60(1.14~2.24)^a)	1.12(0.88~1.42)	1.45(1.14~1.83)^a)
Log [皮下脂肪面积([cm²)]	1.23(0.98~1.54)	1.13(0.73~1.75)	1.42(0.97~2.10)	1.28(0.98~1.68)	1.39(1.11~1.74)^a)
Log [内脏脂肪面积(cm²)]	1.16(0.93~1.44)	1.71(1.08~2.72)^b)	1.52(1.08~2.15)^b)	1.30(1.00~1.68)^b)	1.41(1.13~1.76)^a)

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