Abstract: Objective: To investigate whether the existed local inflammation and general micro-inflammation during arteriovenous fistula operation would predict the stenosis of arteriovenous fistula(AVF) in site of cannulation with buttonhole technique thereafter. Methods: Twenty-three patients with chronic kidney disease(CKD) stage 5 were allocated into 2 groups according to the expression of MCP-1 on the wall of radial artery during the operation of constructing AVF: low MCP-1 expression group and high MCP-1 expression group. All of the AVF were cannulated with buttonhole technique and followed up for 48 months. Results: The stenosis rate of cannulation site was 5 per 560 patient-month in low MCP-1 expression group, 8 per 209 patient-month in high MCP-1 expression group (u=-2.080, P<0.05). Compared with low MCP-1 expression group, the Hazzar ratio for high MCP-1 expression group to develop cannulation site stenosis was 0.08 (95% CI: 0.02-0.32, P<0.01). COX analysis revealed that high MCP-1 expression on radial artery and high level of hsCRP were the risk factors for cannulation site stenosis and the HR were 1.008 and 17.84, respectively(P<0.05). Conclusions: The expression of MCP-1 on radial artery and the level of hsCRP could predict the stenosis of the cannulation site of AVF with buttonhole.

Key words: Inflammation, Arteriovenous fistula, Stenosis