Clinicopathologic analysis of skin melanocyte lesions

doi:10.16150/j.1671-2870.2018.05.016

Abstract

Abstract: Objective: To explore the clinicopathologic features and differential diagnosis of cutaneous melanocyte lesions. Methods: The clinical manifestation, morphology and immunophenotypic characteristics of 1 case of blue nevus, 1 case of borderline nevus and 1 case of malignant lentigo maliana melanoma were analyzed. Results: The 3 cases had lesions located in skin with different sizes, showing melanin cell hyperplasia, with various growth pattern and degree of differentiation and overlapping in existing. Immunohistochemical tests showed that the proliferated cells in all 3 cases had positive expressions of S-100 protein and HMB45. Conclusions: Various pathological types of melanocyte lesions are seen. Histopathology and immunohistochemistry showed different degrees of similarity, and the differentiation of benign and malignant lesions was very difficult. Clinicians should consider comprehensively the clinical characteristics, gross features, microscopic findings, immune phenotype and supplemented by molecular detection if necessary to make an accurate diagnosis.

Key words: Skin, Melanocytic lesions, Pathological examination, Differential diagnosis

CLC Number:

R733.2

YANG Ruxue, LI Nan, ZHOU Ting, ZHAO Yan, CHEN Shaohua, ZHU Qing, FENG Zhenzhong. Clinicopathologic analysis of skin melanocyte lesions[J]. Journal of Diagnostics Concepts & Practice, 2018, 17(05): 566-571.

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