Value of quantitative assay of urinary LH and FSH in differentiating classic from transitional premature thelarche

doi:10.16150/j.1671-2870.2019.03.009

Abstract

Abstract:

Objective: To investigate the value of quantitative assay of urinary FSH and LH in differentiating classic from transitional premature thelarche. Methods: A total of 112 girls with breast development before 8 years of age and undergone both LHRH stimulation and urinary LH and urinary UFSH assay were enrolled. Of them 53 girls with CPP (central precocious puberty) started treatment immediately, whereas the other 49 girls were observed 6 months for pubertal advancement, gonadal hormone, height acceleration, and bone age maturation, and were categorized into two groups: the classic premature thelarche group and the transitional premature thelarche group. Results: In both groups, the serum LH level was positively correlated with morning urinary LH level. The morning urinary LH/FSH of girls at first visit in classic premature thelarche and transitional premature thelarche were 0.50±0.35 and 1.16±1.08, respectively, the difference was statistically significant (P<0.05). Urinary LH/FSH could differentiate girls with classic premature thelarche from transitional premature thelarche. Receiver operating characteristics analysis showed an LH/FSH cutoff value of 0.512, sensitivity of 80% and specificity of 56%. Conclusions: Urinary LH/FSH assay is a noninvasive, reliable method that can assist the differentiation between classic from transitional premature thelarche.

Key words: Premature thelarche, Urinary luteintizing honmone, Urinary follicle stimulating hormone

CLC Number:

R725.8

MA Xiaoyu, LU Wenli, NI Jihong, WANG Junqi, CHEN Ye, Qin Xueyan, DONG Zhiya, WANG Wei. Value of quantitative assay of urinary LH and FSH in differentiating classic from transitional premature thelarche[J]. Journal of Diagnostics Concepts & Practice, 2019, 18(03): 291-295.

Figures/Tables 5

References 11

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项目	经典型PT	过渡型PT	P值
血LH基值（IU/L）	0.14±0.05	0.17±0.04	0.57
血LH峰值（IU/L）	2.67±1.59	3.14±1.29	0.35
血FSH基值（IU/L）	1.48±0.67	2.02±1.23	0.06
血FSH峰值（IU/L）	10.45±6.93	10.50±5.04	0.97
血LH/FSH峰值比值	0.38±0.12	0.39±0.11	0.93
晨尿LH（IU/L）	1.30±0.27	2.35±0.99	0.12
晨尿FSH（IU/L）	3.45±1.20	2.78±1.52	0.49
晨尿LH/FSH比值半年后血LH峰值（IU/L）半年后血FSH峰值（IU/L）	0.50±0.35 2.56±1.09 10.43±5.50	1.16±1.08 5.75±0.49 8.26±0.88	0.02 <0.01 0.10

项目	经典型（n=24）	过渡型（n=25）
乳房发育年龄（岁）	5.68±1.60	6.14±1.51
入院检查年龄（岁）	6.11±1.11	6.76±1.02
骨龄 (岁)	6.01±1.80	7.91±1.52
身高标准差积分	0.66±0.33	1.02±0.71
体质量指数（kg/m²）	12.80±2.64	16.00±2.22

项目	晨尿LH/FSH	血清LH/FSH 峰值比值	血清LH峰值
最佳临界值	≥0.512	≥0.290	≥0.596
ROC曲线下面积	0.722	0.640	0.596
灵敏度	80.0%	60.0%	53.3%
特异度	55.6%	73.2%	73.2%