Journal of Diagnostics Concepts & Practice ›› 2020, Vol. 19 ›› Issue (02): 115-121.doi: 10.16150/j.1671-2870.2020.02.004
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XIAO Chao, TAO Ying, SONG Luxi, ZHAO Youshan, WU Lingyun, CHANG Chunkang()
Received:
2019-02-27
Online:
2020-04-25
Published:
2020-04-25
Contact:
CHANG Chunkang
E-mail:changchunkang@sina.com
CLC Number:
XIAO Chao, TAO Ying, SONG Luxi, ZHAO Youshan, WU Lingyun, CHANG Chunkang. Clinical analysis of 88 patients with myeloproliferative neoplasm[J]. Journal of Diagnostics Concepts & Practice, 2020, 19(02): 115-121.
参数 | PV(n=20) | ET(n=23) | pre-PMF(n=23) | overt-PMF(n=22) | P值 |
---|---|---|---|---|---|
性别(男/女) | 14/6 | 7/16 | 12/11 | 13/9 | 0.062 |
年龄(岁) | 61(20~82) | 57(21~88) | 61(21~77) | 65(29~86) | 0.724 |
≥65岁 | 7(35%) | 7(30%) | 7(30%) | 11(50%) | 0.051 |
突变情况 | |||||
JAK2 V617F突变 | 15(75%) | 14(61%) | 10(43%) | 12(55%) | 0.214 |
CALR突变 | 0 | 1(4%) | 0 | 4(18%) | 0.027 |
MPL突变 | 0 | 2(9%) | 0 | 0 | 0.125 |
三阴性 | 5(25%) | 6(26%) | 13(57%) | 6(27%) | 0.072 |
脾肿大 | 3(15%) | 1(4%) | 6(26%) | 12(55%) | 0.001 |
明显的骨髓纤维化 | 8(40%) | 7(30%) | 0 | 22(100%) | <0.001 |
白细胞增多[n(%)] | 3(15%) | 4(17%) | 14(61%) | 17(77%) | 0.008 |
血红蛋白含量降低 | 0 | 1(4%) | 5(22%) | 11(50%) | <0.001 |
血小板计数降低(n) | 1(5%) | 0 | 1(4%) | 6(27%) | 0.003 |
LDH均值(U/L) | 254.0±150.8 | 316.0±271.3 | 328.0±255.8 | 668.0±388.9 | 0.010 |
骨髓巨核细胞中位数(个/mm2) | 42(3~120) | 51(1~93) | 23(6~107) | 127(11~273) | <0.001 |
参数 | JAK2 V617F突变(n=51) | 三阴性(n=30) | CALR突变(n=5) | MPL突变(n=2) | P值 |
---|---|---|---|---|---|
性别(男/女) | 23/28 | 20/10 | 3/2 | 0/2 | 0.057 |
年龄(岁) | 64(29~88) | 52(20~79) | 46(21~63) | 64(61~67) | 0.027 |
≥65岁 | 24(47%) | 7(23%) | 0 | 1(50%) | 0.281 |
脾肿大 | 12(24%) | 8(27%) | 2(40%) | 0 | 0.060 |
白细胞增多 | 24(47%) | 12(40%) | 4(80%) | 0 | 0.439 |
血红蛋白含量降低 | 8(16%) | 8(27%) | 1(20%) | 0 | 0.914 |
血小板计数降低 | 4(8%) | 4(13%) | 1(20%) | 0 | 0.015 |
LDH均值(U/L) | 402±339 | 348±265 | 839±88 | 153±32 | 0.443 |
中重度骨髓纤维化 | 24(47%) | 8(27%) | 5(100%) | 0 | 0.001 |
骨髓巨核细胞中位数(个/mm2) | 52(6~273) | 28(3~82) | 111(70~120) | 88(85~91) | 0.234 |
参数 | ET组(n=23) | pre-PMF组(n=23) | overt-PMF组(n=22) | P1值 | P2值 |
---|---|---|---|---|---|
性别(男/女) | 7/16 | 12/11 | 13/9 | 0.134 | 0.641 |
年龄(岁) | 57(21~88) | 61(21~77) | 65(29~86) | 0.969 | 0.313 |
≥65岁 | 7(30%) | 7(30%) | 11(50%) | 1.000 | 0.181 |
脾肿大 | 1(4%) | 6(26%) | 12(55%) | 0.043 | 0.051 |
白细胞增多 | 4(17%) | 14(61%) | 17(77%) | 0.007 | 0.235 |
血红蛋白含量降低 | 1(4%) | 5(22%) | 11(50%) | 0.189 | 0.048 |
血小板计数降低 | 0 | 1(4%) | 6(27%) | 1.000 | 0.034 |
LDH均值(U/L) | 316.0±271.3 | 328.0±255.8 | 668.0±388.9 | 0.922 | 0.037 |
项目 | pre-PMF | overt-PMF | |||||
---|---|---|---|---|---|---|---|
JAK2 V617F突变(n=10) | 三阴性(n=13) | P值 | JAK2 V617F突变(n=12) | 三阴性(n=6) | P值 | ||
性别(男/女) | 3/7 | 9/4 | 0.463 | 9/3 | 3/3 | 0.294 | |
年龄(岁) | 65(35~77) | 50(21~75) | 0.030 | 63(29~71) | 71(43~79) | 0.982 | |
≥65岁 | 5(50%) | 2(15%) | 0.092 | 4(33%) | 4(67%) | 0.201 | |
脾肿大 | 0 | 6(46%) | 0.017 | 8(67%) | 2(33%) | 0.321 | |
白细胞增多 | 7(70%) | 7(54%) | 0.363 | 9(75%) | 4(67%) | 0.561 | |
血红蛋白含量降低 | 1(10%) | 4(31%) | 0.251 | 4(33%) | 4(67%) | 0.201 | |
血小板计数降低 | 0 | 1(8%) | 0.565 | 5(42%) | 1(17%) | 0.306 | |
LDH均值(U/L) | 472±343 | 257±198 | 0.260 | 682±443 | 448±414 | 0.527 |
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