Journal of Diagnostics Concepts & Practice ›› 2020, Vol. 19 ›› Issue (02): 139-144.doi: 10.16150/j.1671-2870.2020.02.008
• Original articles • Previous Articles Next Articles
SHAO Dandan1a, FU Yang2, LUO Qi2, CHEN Jie2, MA Jianfang2, HUANG Lei1b()
Received:
2019-10-10
Online:
2020-04-25
Published:
2020-04-25
Contact:
HUANG Lei
E-mail:huangleolina@163.com
CLC Number:
SHAO Dandan, FU Yang, LUO Qi, CHEN Jie, MA Jianfang, HUANG Lei. Serum uric acid and Parkinson disease: a population-based prospective study[J]. Journal of Diagnostics Concepts & Practice, 2020, 19(02): 139-144.
参数 | 总样本 (n=886) | 非高UA组 (n=294) | 高UA组 (n=592) | P值 |
---|---|---|---|---|
年龄(岁) | 67.01±7.56 | 68.51±6.78 | 66.27±7.81 | <0.001 |
男性[n(%)] | 362(40.9) | 115(39.1) | 247(41.7) | 0.457 |
文化程度[n(%)] | ||||
文盲 | 231(26.1) | 86(29.3) | 145(24.5) | 0.290 |
小学毕业 | 367(41.4) | 119(40.5) | 248(41.9) | |
初中毕业及以上 | 288(32.5) | 89(30.3) | 199(33.6) | |
体质量指数(kg/m2) | 24.16±3.32 | 23.48±3.42 | 24.50±3.21 | <0.001 |
便秘[n(%)]* | 65(7.5) | 19(7.0) | 46(7.8) | 0.685 |
排尿障碍[n(%)] | 42(4.8)* | 12(4.4)* | 30(5.1) | 0.683 |
睡眠时间(h) | 6.78±1.50 | 6.58±1.62 | 6.88±1.43 | 0.006 |
打鼾[n(%)] | 381(46.0)* | 111(41.7)* | 270(48.0) | 0.089 |
运动情况[n(%)]* | ||||
不太活动 | 145(16.5) | 48(16.4) | 97(16.5) | 0.885 |
轻度活动 | 361(41.0) | 123(42.1) | 238(40.5) | |
中度活动 | 374(42.5) | 121(41.4) | 253(43.0) | |
独居[n(%)]* | 69(7.8) | 30(10.4) | 39(6.6) | 0.051 |
经常饮绿茶[n (%)]* | 164(18.5) | 43(14.8) | 121(20.5) | 0.040 |
经常饮奶制品[n(%)]* | 216(24.5) | 72(24.7) | 144(24.4) | 0.913 |
吸烟史[n(%)]* | 233(26.5) | 61(21.0) | 172(29.2) | 0.010 |
目前吸烟* | 186(21.2) | 51(17.6) | 135(22.9) | 0.072 |
饮酒史[n(%)]* | 168(19.1) | 46(15.8) | 122(20.7) | 0.082 |
目前饮酒* | 163(18.5) | 46(15.8) | 117(19.8) | 0.148 |
利血平使用史[n(%)]* | 134(17.5) | 34(13.7) | 100(19.4) | <0.050 |
非甾体抗炎药使用 史[n(%)]* | 146(19.9) | 44(18.4) | 102(20.6) | 0.485 |
阿司匹林使用史* | 47(6.1) | 15(6.0) | 32(6.1) | 0.949 |
高血压[n(%)]* | 638(72.0) | 185(62.9) | 453(76.5) | <0.001 |
糖尿病[n(%)]* | 239(27.0) | 75(25.5) | 164(27.7) | 0.489 |
冠心病[n(%)] | 84(9.5)* | 26(8.8)* | 58(9.8) | 0.643 |
痴呆家族史[n(%)]* | 41(4.8) | 12(4.5) | 29(4.9) | 0.785 |
脑卒中家族史[n(%)]* | 63(7.3) | 23(8.6) | 40(6.8) | 0.347 |
高脂血症[n (%)] | 214(24.2)* | 51(17.3) | 163(27.6) | 0.001 |
总胆固醇(mmol/L) | 4.93±1.01 | 4.93±0.99 | 4.93±1.02 | 0.955 |
甘油三酯(mmol/L) | 1.88±1.33 | 1.60±1.20 | 2.00±1.36 | <0.001 |
血肌酐(mmol/L) | 71.60±22.58 | 67.09±14.58 | 74.00±25.54 | <0.001 |
新发PD[n (%)] | 22(2.5) | 4(1.4) | 18(3.0) | 0.130 |
因素 | HR(95%CI) | P值 |
---|---|---|
年龄(每上升1岁) | 1.073(1.019~1.130) | 0.007 |
女性 | 1.827(0.715~4.669) | 0.208 |
文化程度 | ||
文盲 | 1.000 | - |
小学毕业 | 0.397(0.154~1.025) | 0.056 |
初中毕业及以上 | 0.286(0.091~0.897) | 0.032 |
运动情况 | ||
不太活动 | 1.000 | - |
轻度活动 | 0.706(0.207~2.410) | 0.578 |
中度活动 | 0.981(0.308~3.127) | 0.974 |
体质量指数(每上升1 kg/m2) | 0.980(0.863 ~1.113) | 0.758 |
便秘 | 0.618(0.083~4.608) | 0.639 |
排尿障碍 | 1.041(0.140~7.755) | 0.969 |
睡眠时间(每增加1 h) | 0.875(0.662~1.157) | 0.348 |
打鼾 | 2.149(0.834~5.538) | 0.113 |
独居 | 1.975(0.582~6.705) | 0.275 |
经常饮绿茶 | 0.219(0.029~1.629) | 0.138 |
经常饮奶制品 | 1.542(0.622~3.821) | 0.349 |
吸烟史 | 0.824(0.304~2.233) | 0.703 |
目前吸烟 | 0.880(0.296~2.614) | 0.817 |
饮酒史 | 0.201(0.027~1.494) | 0.117 |
目前饮酒 | 0.219(0.029~1.630) | 0.138 |
利血平使用史 | 1.339(0.441~4.069) | 0.606 |
非甾体抗炎药使用史 | 1.558(0.555~4.370) | 0.400 |
阿司匹林使用史 | 1.929(0.444~8.389) | 0.381 |
高血压 | 1.767(0.598~5.220) | 0.303 |
糖尿病 | 1.019(0.399~2.603) | 0.969 |
冠心病 | 1.521(0.450~5.139) | 0.500 |
痴呆家族史 | 0.046(0.000~361.8) | 0.502 |
脑卒中家族史 | 0.044(0.000~62.45) | 0.400 |
高脂血症 | 0.691(0.234~2.043) | 0.504 |
总胆固醇(每升高1 mmol/L) | 0.869(0.558~1.351) | 0.532 |
甘油三酯(每升高1 mmol/L) | 0.603(0.347~1.049) | 0.073 |
血肌酐(每升高1 mmol/L) | 0.975(0.949~1.002) | 0.074 |
高UA血症 | 2.072(0.701~6.121) | 0.188 |
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