Abstract:

Objective: To investigate the incidence and risk factors of hypoxia during performing gastroscopy with propofol sedation and provide theoretical basis for preventing hypoxia. Methods: From November 2017 to February 2018, a total of 1 000 outpatients undergoing routine gastroscopy with propofol sedation were enrolled,and the incidence of hypoxia and the other adverse events were recorded during performing gastroscopy. The patients were divided into two groups: hypoxia group and non-hypoxia group, and the general information, gastroscopy procedure and anesthesia related information were analyzed. Results: The incidence of hypoxia was 8.4% during gastroscopic examination. It revealed that the history of hypertension and snoring, elderly age, body mass index (BMI), American Society of Anesthesiologists (ASA) classification, shorter thyromental distance, number of passing the gastroscope through the pharyngeal, high dose of propofol and low baseline of SpO₂ were risk factors for occurrence of hypoxia during performing gastroscopy with propofol sedation (P<0.05). Age (45-65 years old, OR=2.903, 95% CI: 1.399-6.026,>65 years old, OR=5.495, 95% CI: 2.124-14.211), the dose of propofol (80-100 mg, OR=3.289, 95%CI: 1.215-8.906; 101-120 mg, OR=5.881, 95%CI: 1.964-17.615; >120 mg, OR=7.717, 95%CI: 2.664-22.351) and lower baseline of SpO₂ (<95%, OR=3.327, 95% CI:1.173-9.439) were independent risk factors for hypoxia. Conclusions: Elderly patients (over 65 years old), the patients obtaining high dose of propofol (>120 mg) and with lower baseline SpO₂ (<95%) have increased risk of hypoxia during gastroscopic examination with propofol sedation, and the hypoxia should be actively prevented and interfered.

Key words: Gastroscopy, Sedation, Hypoxia, Propofol, Risk factors