Abstract:

Pemphigus is a severe autoimmune disease causing damage of epidermis and mucosa. Patients can produce autoantibodies against structures like intercellular adhesion, which leads to disease. Main pathogenic antibodies include anti-Gsg1 and anti-Gsg3 which cause disease primarily through steric hindrance and signal transduction after antigen-antibody binding. Other antibodies such as anti-Dsc, anti-plakin family, anti-acetylcholine receptor etc. also play an important synergistic effect in the pathogenic process. With the popularization of immunofluorescence, ELISA and other technologies, antibody detection has become an important method for clinical diagnosis and monitoring of pemphigus. Couples of clinical studies have shown that the titers of anti-Dsg1 and Dsg3 antibodies are related to the activity of pemphigus disease, which can also indicate the recurrence of the disease and guide clinical medication. More mechanism research and clinical exploration of pemphigus autoantibodies will help us to cognize the disease further.

Key words: Pemphigus, Autoantibody, Desmogelin, Efficacy monitoring