Journal of Diagnostics Concepts & Practice ›› 2024, Vol. 23 ›› Issue (04): 416-423.doi: 10.16150/j.1671-2870.2024.04.010
• Original articles • Previous Articles Next Articles
FU Xina, XU Xin, LI Tianjie, JIN Ying()
Received:
2024-03-09
Accepted:
2024-08-13
Online:
2024-08-25
Published:
2024-08-25
Contact:
JIN Ying
E-mail:13501362591@163.com
CLC Number:
FU Xina, XU Xin, LI Tianjie, JIN Ying. Study on the risk factors for persistent infection of high-risk human papillomavirus after cervical conization[J]. Journal of Diagnostics Concepts & Practice, 2024, 23(04): 416-423.
Table 1
Comparison of HR-HPV infection before cervical conization between HR-HPV persistent infection group and HR-HPV clearance group [n(%)]
Before surgery | Status | HR-HPV after conization | χ2 | P | |
---|---|---|---|---|---|
Persistent infection group (n=168) | Clearance group (n=299) | ||||
HPV 16 / 18 infection before surgery | Yes | 80(47.6) | 159(53.2) | 1.330 | 0.249 |
No | 88(52.4) | 140(46.8) | |||
Any type of HPV 16,52 or 58 infection | Yes | 71(42.3) | 85(28.4) | 9.253 | 0.002 |
No | 97(57.7) | 214(71.6) | |||
HR-HPV infection | Single type | 78(46.4) | 194(64.9) | 15.062 | <0.001 |
Multiple type | 90(53.6) | 105(35.1) |
Table 2
Risk factors for HR-HPV persistent infection after cervical conization[n(%)]
Variation | HR-HPV persitent infection group (n=168) | HR-HPV after conization clearnce group (n=299) | χ2 | P | |
---|---|---|---|---|---|
Menopause | No | 104(29.1) | 254(70.9) | 31.926 | <0.001 |
Yes | 64(58.7) | 45(41.3) | |||
TCT | <HSIL | 139(82.7) | 212(70.9) | 8.070 | 0.005 |
≥HSIL | 29(17.3) | 87(29.1) | |||
Pathological biopsy | <HSIL | 28(16.7) | 28(9.4) | 5.435 | 0.020 |
≥HSIL | 140(83.3) | 271(90.6) | |||
Margin | Clean | 137(81.5) | 272(91.0) | 8.779 | 0.003 |
Nnclean | 31(18.5) | 27(9.0) | |||
Glands involvement | Yes | 91(54.2) | 124(41.5) | 6.978 | 0.008 |
No | 77(45.8) | 175(58.5) | |||
Surgery | LEEP | 155(92.3) | 238(79.6) | 12.935 | <0.001 |
CKC | 13(7.7) | 61(20.4) |
Table 3
Multivariate Logistic regression analysis of risk factors for HR-HPV persistent infection after cervical conization
Variation | Single factor analysis | Multiple factor analysis | |||
---|---|---|---|---|---|
OR(95%CI) | P | OR(95%CI) | P | ||
Menopause | 3.474(2.227~5.417) | <0.001 | 3.453(2.146~5.555) | <0.001 | |
Any type of HPV16,52 or 58 infection before surgery | 1.843(1.240~2.738) | 0.002 | |||
Multiple type of HR-HPV infection before surgery | 2.887(1.993~4.182) | <0.001 | 2.683(1.825~3.944) | <0.001 | |
TCT<HSIL | 1.967(1.227~3.152) | 0.005 | 1.884(1.130~3.142) | 0.015 | |
Pathological biopsy<HSIL | 3.056(1.624~5.749) | 0.001 | |||
Glands | 1.668(1.140~2.441) | 0.008 | |||
Margin clean | 1.675(1.169~2.398) | 0.005 | 1.479(1.003~2.181) | 0.048 | |
LEEP | 3.056(1.624~5.749) | 0.001 | 2.330(1.193~4.551) | 0.013 |
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